OAB-045: COVID-19 vaccine responsiveness in patients with Multiple Myeloma and Waldenström Macroglobulinemia

Autor: Emerentia Agyemang, Clifton C. Mo, Galit Alter, Raquel Gallagher, Paul G. Richardson, Boris Juleg, Shayna Sarosiek, Omar Nadeem, Andrew R. Branagan, Zachary Bernstein, Noopur Raje, Cristina Panaroni, Allison Maebius, Matthew Lei, Steven P. Treon, Andrew Yee, Jill N. Burke, Elizabeth O'Donnell, Matthew J. Waterman, Jorge J. Castillo, Chukwuamaka Onyewadume, Catherine A Flynn, Rebecca Lyons, Cynthia C. Harrington, Kirsten Meid
Rok vydání: 2021
Předmět:
Zdroj: Clinical Lymphoma, Myeloma & Leukemia
ISSN: 2152-2650
DOI: 10.1016/s2152-2650(21)02119-4
Popis: Background Multiple myeloma (MM) and Waldenström macroglobulinemia (WM) are associated with significant immunoparesis. Based on the ongoing COVID-19 pandemic, there is an urgent need to understand whether patients are able to mount a sufficient response to COVID-19 vaccines. Methods Patients were vaccinated with BNT162b2 mRNA (Pfizer/BioNTech), mRNA-1273 (Moderna), or JNJ-78436735 (Johnson & Johnson). SARS-CoV-2 spike protein (S) antibodies were detected with the Elecsys assay (Roche Diagnostics). Primary endpoint is S antibody detection 28 days after final vaccination. Secondary endpoints include functional serologic assessments and T-cell responses at 28 days, 6 months, 9 months, and 12 months. Results 141 patients have been enrolled to date, 136 (91 MM and 45 WM) of whom had initial S antibody assessment. Median antibody titer was 178.0 (IQR, 16.10-1166.0) for MM and 3.96 (IQR, 0-282.8) for WM. S antibody response rate was 91% (83/91) in MM and 60% (27/45) in WM. However, response rates for achieving S antibody >100 U/mL were 56% (51/91) in MM and 33% (15/45) in WM. Vaccine-specific S antibody responses following mRNA-1273, BNT162b2, and JNJ-78436735 were 74% (25/34; p100 u/mL occurred in 45% (9/20) as opposed to 65% (35/54) for VGPR+ (p100 U/mL occurred in 53% (19/36) and 56% (31/55), respectively (p=NS). Among WM patients, S antibody responses >100 U/mL occurred in 73% (8/11) (p
Databáze: OpenAIRE
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