| Autor: |
Ohad Yogev, Omer Weissbrod, Giorgia Battistoni, Dario Bressan, Adi Naamti, Ilaria Falciatori, Ahmet C. Berkyurek, Roni Rasnic, Myra Hosmillo, Shaul Ilan, Iris Grossman, Lauren McCormick, Christopher C. Honeycutt, Timothy Johnston, Matthew Gagne, Daniel C. Douek, Ian Goodfellow, Gregory J. Hannon, Yaniv Erlich |
| Rok vydání: |
2022 |
| Zdroj: |
bioRxiv : the preprint server for biology. |
| Popis: |
Expanding the arsenal of prophylactic approaches against SARS-CoV-2 is of utmost importance, specifically those strategies that are resistant to antigenic drift in Spike. Here, we conducted a screen with over 16,000 RNAi triggers against the SARS-CoV-2 genome using a massively parallel assay to identify hyper-potent siRNAs. We selected 10 candidates for in vitro validation and found five siRNAs that exhibited hyper-potent activity with IC50 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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