An Increased Incidence of Thyroid Antibodies in Patients with Turner's Syndrome and their First Degree Relatives
| Autor: | Malcolm D. C. Donaldson, Rhoda Wilson, John A. Thomson, James H. McKillop, John M. Connor, Carol E. Chu |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Adolescent endocrine system diseases medicine.medical_treatment Immunology Thyroid Gland Thyrotropin Turner Syndrome Autoimmunity Enzyme-Linked Immunosorbent Assay Iodide Peroxidase Thyroglobulin Gastroenterology Antibodies Thyroid peroxidase Internal medicine Turner syndrome Humans Immunology and Allergy Medicine First-degree relatives Child Family Health biology business.industry Incidence Thyroid disease Incidence (epidemiology) Thyroid Infant Middle Aged medicine.disease Anti-thyroid autoantibodies Thyroxine medicine.anatomical_structure Endocrinology Child Preschool Karyotyping biology.protein Female business |
| Zdroj: | Autoimmunity. 25:47-52 |
| ISSN: | 1607-842X 0891-6934 |
| DOI: | 10.3109/08916939608994725 |
| Popis: | Previous studies have suggested that there may be a link between Turner's syndrome and autoimmunity. The numbers involved in these studies have tended to be small and few studies have included family members. This study has compared the incidence of thyroid antibodies in the serum of 60 patients with Turner' syndrome and 50 of their mothers with 127 controls. Total T4 and TSH levels were also measured. Of the 60 patients with Turner's syndrome 18 (30%) were positive for either thyroid peroxidase (TPO) and/or thyroglobulin antibodies. The peak incidence of thyroid antibodies occurred at 13 years of age. 11 (22%) of the mothers were also antibody positive. The incidence of thyroid antibodies was significantly higher in both the patients with Turner's Syndrome (30 vs 1.7% p < 0.001) and their mothers (22 vs 6.6% p < 0.05) than in the control groups. The increased incidence of thyroid antibodies found in these patients and their mothers confirms that there is an association between Turner's Syndrome and autoimmunity. However unlike previous studies we found more patients were positive for thyroglobulin than TPO antibodies. |
| Databáze: | OpenAIRE |
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