Single Pulse Electrical Stimulation to identify epileptogenic cortex: Clinical information obtained from early evoked responses
| Autor: | Frans S. S. Leijten, M.A. van ‘t Klooster, G.J. Hebbink, D. Keizer, Maeike Zijlmans, Cyrille H. Ferrier, Geertjan Huiskamp, Brian E. Mouthaan, M.J.A.M. van Putten |
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| Přispěvatelé: | Clinical Neurophysiology |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Neurology Adolescent Clinical Neurology Sensory system Stimulation High frequency oscillations 050105 experimental psychology 03 medical and health sciences Young Adult 0302 clinical medicine Epilepsy surgery Cortex (anatomy) Physiology (medical) Clinical information Intracranial electrodes Medicine Humans 0501 psychology and cognitive sciences Child Electrocorticography Cerebral Cortex Brain Mapping Epilepsy medicine.diagnostic_test business.industry 05 social sciences Single pulse Electroencephalography Evoked potentials EWI-26948 Sensory Systems Electric Stimulation Electrodes Implanted medicine.anatomical_structure Electrical stimulation Female Neurology (clinical) business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Clinical Neurophysiology, 127(2), 1088. Elsevier Ireland Ltd Clinical neurophysiology, 127(2), 1088-1098. Elsevier |
| ISSN: | 1872-8952 1388-2457 |
| Popis: | Objective: Single Pulse Electrical Stimulation (SPES) probes epileptogenic cortex during electrocorticography. Two SPES responses are described: pathological delayed responses (DR, >100 ms) associated with the seizure onset zone (SOZ) and physiological early responses (ER, 80 Hz, in the SOZ and seizure propagation areas. Methods: We used data from 12 refractory epilepsy patients. SPES consisted of 10 pulses of 1 ms, 4–8 mA and 5 s interval on adjacent electrodes pairs. Data were available at 2048 samples/s for six and 512 samples/s (22 bits) for eight patients and analyzed in the time–frequency (TF) and time-domain (TD). Results: Electrodes with ERs were stronger associated with SOZ than non-SOZ electrodes. ERs with frequency content >80 Hz exist and are specific for SOZ channels. ERs evoked by stimulation of seizure onset electrodes were associated with electrodes involved in seizure propagation. Conclusion: Analysis of ERs can reveal aspects of pathology, manifested by association with seizure propagation and areas with high ER numbers that coincide with the SOZ. Significance: Not only DRs, but also ERs could have clinical value for mapping epileptogenic cortex and help to unravel aspects of the epileptic network. |
| Databáze: | OpenAIRE |
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