Effect of thalidomide on endostatin levels in retinal ischemia/reperfusion injury
| Autor: | Nevin Ilhan, Semih Aydoğan, Ülkü Çeliker, Peykan Türkçüoğlu |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Guinea Pigs Ischemia Urology macromolecular substances Retina Lesion Guinea pig chemistry.chemical_compound medicine Animals cardiovascular diseases Intubation Gastrointestinal Vascular disease business.industry Retinal Vessels Retinal General Medicine medicine.disease Sensory Systems Endostatins Thalidomide Ophthalmology chemistry Anesthesia Reperfusion Injury cardiovascular system medicine.symptom Endostatin business Reperfusion injury medicine.drug |
| Zdroj: | Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde. 221(6) |
| ISSN: | 1423-0267 |
| Popis: | Aim: To evaluate the effects of thalidomide treatment on endostatin production in ischemia/reperfusion-injured guinea pigs retinas. Methods: Control, ischemia, thalidomide/ischemia groups including 7 animals in each were formed from pigmented male guinea pigs. Retinal ischemia was induced by cannulating anterior chambers and lifting the bottle to a height of 205 cm for 90 min in the ischemia and thalidomide/ischemia groups. The thalidomide/ischemia group received thalidomide (300 mg/kg/day) via nasogastric tube 24 h before ischemia and during 7 days of reperfusion. Guinea pigs were scarified for biochemical analysis of retinal endostatin level by ELISA. Results: The mean retinal endostatin levels of the control, ischemia and thalidomide/ischemia groups were 11.79 ± 7.36, 14.70 ± 4.88, 30.94 ± 15.59 ng/ml, respectively. The mean retinal endostatin level of the thalidomide/ischemia group was significantly higher than that of the control group (p = 0.011). The mean retinal endostatin level of the thalidomide/ischemia group was higher than that of the ischemia group, but there was no statistically significant difference (p = 0.073). No statistically significant difference in the mean retinal endostatin level was found between the control and ischemia groups (p = 0.165). Conclusion: Thalidomide treatment increased retinal endostatin level in ischemia/reperfusion-injured guinea pig retinas. |
| Databáze: | OpenAIRE |
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