Higher linezolid exposure and higher frequency of thrombocytopenia in patients with renal dysfunction
| Autor: | Katsushi Yamada, Norifumi Morikawa, Kazuaki Matsumoto, Akari Shigemi, Yasuo Takeda, Keiko Yaji, Yoshihiro Shimodozono, Kazuro Ikawa, Ayumi Takeshita |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Microbiology (medical) medicine.medical_specialty Administration Oral Renal function Gastroenterology Blood Urea Nitrogen chemistry.chemical_compound Anti-Infective Agents Japan Pharmacokinetics Risk Factors Internal medicine Acetamides medicine Humans Pharmacology (medical) Trough Concentration Renal Insufficiency Adverse effect Blood urea nitrogen Oxazolidinones Aged Antibacterial agent Kidney business.industry Linezolid General Medicine Thrombocytopenia Surgery Infectious Diseases medicine.anatomical_structure chemistry Creatinine Injections Intravenous Female business |
| Zdroj: | International Journal of Antimicrobial Agents. 36:179-181 |
| ISSN: | 0924-8579 |
| DOI: | 10.1016/j.ijantimicag.2010.02.019 |
| Popis: | The major adverse event associated with linezolid treatment is reversible myelosuppression, mostly thrombocytopenia. Recent studies have reported that the incidence of linezolid-induced thrombocytopenia was higher in patients with renal failure than in patients with normal renal function, although the underlying mechanisms of this toxicity are still unknown. The present study thus aimed to investigate the relationship between renal function and linezolid exposure as well as the effects of drug exposure on thrombocytopenia. A statistically significant (P |
| Databáze: | OpenAIRE |
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