HTR1B and HTR2C in autism spectrum disorders in Brazilian families
| Autor: | G M, Orabona, K, Griesi-Oliveira, E, Vadasz, V L S, Bulcão, V N V O, Takahashi, E S, Moreira, M, Furia-Silva, A M S, Ros-Melo, F, Dourado, S R, Matioli, R, Matioli, P, Otto, M R, Passos-Bueno |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Genotype Disease Biology Polymorphism Single Nucleotide behavioral disciplines and activities mental disorders Receptor Serotonin 5-HT2C Pervasive developmental disorder medicine Humans Family Genetic Predisposition to Disease Autistic Disorder Allele Molecular Biology Alleles 5-HT receptor Genetics General Neuroscience Haplotype Sequence Analysis DNA medicine.disease Developmental disorder Haplotypes Case-Control Studies Receptor Serotonin 5-HT1B Autism Neurology (clinical) Brazil Developmental Biology |
| Zdroj: | Brain Research. 1250:14-19 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2008.11.007 |
| Popis: | Autism spectrum disorders (ASD) is a group of behaviorally defined neurodevelopmental disabilities characterized by multiple genetic etiologies and a complex presentation. Several studies suggest the involvement of the serotonin system in the development of ASD, but only few have investigated serotonin receptors. We have performed a case-control and a family-based study with 9 polymorphisms mapped to two serotonin receptor genes (HTR1B and HTR2C) in 252 Brazilian male ASD patients of European ancestry. These analyses showed evidence of undertransmission of the HTR1B haplotypes containing alleles -161G and -261A at HTR1B gene to ASD (P=0.003), but no involvement of HTR2C to the predisposition to this disease. Considering the relatively low level of statistical significance and the power of our sample, further studies are required to confirm the association of these serotonin-related genes and ASD. |
| Databáze: | OpenAIRE |
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