Assessment of hypolipidemic, anti-inflammatory and antioxidant properties of medicinal plant Erica multiflora in triton WR-1339-induced hyperlipidemia and liver function repair in rats: A comparison with fenofibrate
| Autor: | Rihab Khlifi, Aida Lahmar, Kamel Ghedira, Zaineb Dhaouefi, Mouna Maatouk, Soumaya Kilani-Jaziri, Leila Chekir-Ghedira, Zahar Kalboussi |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Phytochemicals Anti-Inflammatory Agents Aspartate transaminase Hyperlipidemias 010501 environmental sciences Pharmacology Toxicology 030226 pharmacology & pharmacy 01 natural sciences Antioxidants Polyethylene Glycols Lipid peroxidation 03 medical and health sciences Liver disease chemistry.chemical_compound 0302 clinical medicine Fenofibrate Hyperlipidemia medicine Animals Rats Wistar 0105 earth and related environmental sciences Hypolipidemic Agents medicine.diagnostic_test biology business.industry Plant Extracts General Medicine medicine.disease Plant Leaves chemistry Alanine transaminase Liver biology.protein Ericaceae Liver function Lipid profile business medicine.drug |
| Zdroj: | Regulatory toxicology and pharmacology : RTP. 107 |
| ISSN: | 1096-0295 |
| Popis: | Hyperlipidemia is a serious health threat that has been linked to oxidative stress and systemic inflammation, causing among many other disorders essentially liver disease. The current study was conducted to evaluate the antihyperlipidemic, antioxidant and anti-inflammatory potential of methanol leaf extract from Erica multiflora (M-EML). Triton WR-1339-induced hyperlipidemic rats were divided into six groups: control group (CG), hyperlipidemic group (300 mg/kg body weight “BW”) (HG), hyperlipidemic group treated with M-EML (150 and 250 mg/kg) (HG + M-EML), normal rats treated with M-EML (250 mg/kg) and fenofibrate-treated group (HG + FF) (65 mg/kg). After 24 h of administration, triton WR-1339 induced a significant increase in lipid profile, atherogenic index (AI) and Coronary Risk Index (CRI) in HG group compared to control group. Furthermore, triton WR-1339 administration induced alteration in the status of pro-inflammatory markers (aspartate transaminase, alanine transaminase, IFN-γ and Nitric oxide production). HG group showed also, a high level of lipid peroxidation, an altered antioxidant enzyme profiles and an increase in DNA damages, in liver. However, orally administration of M-EML mitigates significantly these disorders, proving hence a protective potential against triton WR-1339-induced hyperlipidemia. These findings suggest that M-EML extract could be used as functional foods and natural adjuvant treatment of hyperlipidemia. |
| Databáze: | OpenAIRE |
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