The contradictory role of androgens in cutaneous and major burn wound healing
Autor: | Roxanne Parungao, Duncan Ma, Zhe Li, Jonathan J. Hew, David J. Handelsman, Ulla Simanainen, Mark S. Cooper, Kenny Cheer, Brian Lesmana, Peter K.M. Maitz, Yiwei Wang, Huaikai Shi |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Matrix remodeling medicine.drug_class Biomedical Engineering Wound healing Inflammation Dermatology Review Critical Care and Intensive Care Medicine Bioinformatics Androgen Mouse model Oxandrolone Cutaneous injury 03 medical and health sciences 0302 clinical medicine Major burn injury Immunology and Allergy Medicine integumentary system business.industry Major burn 030104 developmental biology 030220 oncology & carcinogenesis Emergency Medicine Hypermetabolism Surgery Tumor necrosis factor alpha medicine.symptom business medicine.drug |
Zdroj: | Burns & Trauma |
ISSN: | 2321-3868 |
Popis: | Wound healing is a complex process involving four overlapping phases: haemostasis, inflammation, cell recruitment and matrix remodeling. In mouse models, surgical, pharmacological and genetic approaches targeting androgen actions in skin have shown that androgens increase interleukin-6 and tumor necrosis factor-α production and reduce wound re-epithelization and matrix deposition, retarding cutaneous wound healing. Similarly, clinical studies have shown that cutaneous wound healing is slower in men compared to women. However, in major burn injury, which triggers not only local wound-healing processes but also systemic hypermetabolism, the role of androgens is poorly understood. Recent studies have claimed that a synthetic androgen, oxandrolone, increases protein synthesis, improves lean body mass and shortens length of hospital stay. However, the possible mechanisms by which oxandrolone regulates major burn injury have not been reported. In this review, we summarize the current findings on the roles of androgens in cutaneous and major burn wound healing, as well as androgens as a potential therapeutic treatment option for patients with major burn injuries. |
Databáze: | OpenAIRE |
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