Imaging characteristics of intravascular spherical contrast agents for grating-based x-ray dark-field imaging – effects of concentrations, spherical sizes and applied voltage
| Autor: | Franz Pfeiffer, Susan Notohamiprodjo, Sigrid Auweter, Karla Maria Treitl, Sven-Martin Sutter, Katharina Hellbach, Maximilian F. Reiser, Christian Hauke |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Materials science
Analytical chemistry lcsh:Medicine Contrast Media Drug development Imaging techniques Grating Radiation Dosage 01 natural sciences Article 030218 nuclear medicine & medical imaging 010309 optics 03 medical and health sciences 0302 clinical medicine 0103 physical sciences lcsh:Science Multidisciplinary Microbubbles Scattering Attenuation X-Rays lcsh:R X-ray Dark field microscopy Radiography Preclinical research Conventional PCI lcsh:Q Tomography X-Ray Computed Voltage |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) |
| ISSN: | 2045-2322 |
| Popis: | This study investigates the x-ray scattering characteristics of microsphere particles in x-ray-grating-based interferometric imaging at different concentrations, bubble sizes and tube voltages (kV). Attenuation (ATI), dark-field (DFI) and phase-contrast (PCI) images were acquired. Signal-to-noise (SNR) and contrast-to-noise ratios with water (CNRw) and air as reference (CNRa) were determined. In all modalities, a linear relationship between SNR and microbubbles concentration, respectively, microsphere size was found. A significant gain of SNR was found when varying kV. SNR was significantly higher in DFI and PCI than ATI. The highest gain of SNR was shown at 60 kV for all media in ATI and DFI, at 80 kV for PCI. SNR for all media was significantly higher compared to air and was slightly lower compared to water. A linear relationship was found between CNRa, CNRw, concentration and size. With increasing concentration and decreasing size, CNRa and CNRw increased in DFI, but decreased in PCI. Best CNRa and CNRw was found at specific combination of kV and concentration/size. Highest average CNRa and CNRw was found for microspheres in ATI and PCI, for microbubbles in DFI. Microspheres are a promising contrast-media for grating-based-interferometry, if kV, microsphere size and concentration are appropriately combined. |
| Databáze: | OpenAIRE |
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