A population-based longitudinal study of Clostridium difficile infection-related hospitalization in mid-age and older Australians
Autor: | Katie Glass, Rosemary J. Korda, Thomas V. Riley, Martyn D. Kirk, Yingxi Chen, Bette Liu |
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Rok vydání: | 2016 |
Předmět: |
Diarrhea
Male 0301 basic medicine Pediatrics medicine.medical_specialty Longitudinal study genetic structures Epidemiology 030106 microbiology Population 03 medical and health sciences Sex Factors 0302 clinical medicine Risk Factors medicine Humans Longitudinal Studies Prospective Studies 030212 general & internal medicine Prospective cohort study education Aged Aged 80 and over education.field_of_study Clostridioides difficile Proportional hazards model business.industry Incidence Incidence (epidemiology) Hazard ratio Age Factors Health Care Costs Length of Stay Middle Aged Clostridium difficile Original Papers Hospitalization Infectious Diseases Clostridium Infections Female New South Wales business |
Zdroj: | Epidemiol Infect |
ISSN: | 1469-4409 0950-2688 |
Popis: | SUMMARYClostridium difficile is the principal cause of infectious diarrhoea in hospitalized patients. We investigated the incidence and risk factors for hospitalization due to C. difficile infection (CDI) in older Australians. We linked data from a population-based prospective cohort study (the 45 and Up Study) of 266 922 adults aged ⩾45 years recruited in New South Wales, Australia to hospitalization and death records for 2006–2012. We estimated the incidence of CDI hospitalization and calculated days in hospital and costs per hospitalization. We also estimated hazard ratios (HR) for CDI hospitalization using Cox regression with age as the underlying time variable. Over a total follow-up of 1 126 708 person-years, 187 adults had an incident CDI hospitalization. The crude incidence of CDI hospitalization was 16·6/100 000 person-years, with a median hospital stay of 6 days, and a median cost of AUD 6102 per admission. Incidence increased with age and year of follow-up, with a threefold increase for 2009–2012. After adjustment, CDI hospitalization rates were significantly lower in males than females (adjusted HR 0·6, 95% confidence interval 0·4–0·7). CDI hospitalization rates increased significantly over 2009–2012. There is a need to better understand the increasing risk of CDI hospitalization in women. |
Databáze: | OpenAIRE |
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