Rapid Regression of Fetal Adrenal Zone and Absence of Adrenal Reticular Zone in the Marmoset
| Autor: | Judith Levine, D. Lynn Loriaux, Gordon B. Cutler, Schiebinger Rj, L. Wolfe |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Adult
Male medicine.medical_specialty Hydrocortisone genetic structures Dehydroepiandrosterone Dexamethasone chemistry.chemical_compound Sex Factors Endocrinology Dehydroepiandrosterone sulfate Species Specificity Internal medicine biology.animal Adrenal Glands medicine Animals Humans Castration Fetus biology Dehydroepiandrosterone Sulfate food and beverages Marmoset Callithrix biology.organism_classification chemistry Callitrichinae Reticular connective tissue Female lipids (amino acids peptides and proteins) Saguinus medicine.drug |
| Zdroj: | Endocrinology. 111:1797-1802 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-111-6-1797 |
| Popis: | Developmental changes in plasma dehydropiandrosterone (DHA) and in adrenal histology were studied in several marmoset species (Callithrix jacchus and Saguinus labiatus, nigricollis, and fuscicollis) to evaluate these primates as experimental models for the study of fetal adrenal zone regression. Newborn marmosets had a prominent fetal adrenal zone, plasma DHA levels above 1000 ng/dl, and plasma DHA sulfate (DHAS) levels of 140 micrograms/dl. The fetal zone regressed dramatically during the first week of life, paralleled by a marked decline in plasma DHA, the plasma DHA to cortisol ratio, and plasma DHAS. The adult marmoset, however, had no adrenal reticular zone and no evidence of adrenal DHA secretion; DHA levels in castrate adults were undetectable (less than 25 ng/dl). Thus, the marmoset represents the first example of a primate that has a regressing, DHA- and DHAS-secreting fetal adrenal zone but that does not subsequently develop a DHA-secreting adrenal reticular zone. |
| Databáze: | OpenAIRE |
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