Therapeutic Effect of Metformin on Chemerin in Non-Obese Patients with Non-Alcoholic Fatty Liver Disease (NAFLD)
| Autor: | Nengjun Lou, Zhe Pan, Aili Sun, Xianghua Zhuang, Xiaobo Li, Liang Li, Fudun Sun, Dongqing Jiang, Fuchen Lou, Liang Zhang |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty endocrine system diseases medicine.medical_treatment Administration Oral Blood Pressure digestive system General Biochemistry Genetics and Molecular Biology Insulin resistance Non-alcoholic Fatty Liver Disease Risk Factors Internal medicine medicine Humans Hypoglycemic Agents Insulin Chemerin Risk factor Chimerin 1 biology business.industry Therapeutic effect Fatty liver nutritional and metabolic diseases Drug Synergism Middle Aged medicine.disease Metformin digestive system diseases Logistic Models Endocrinology Blood pressure biology.protein Female Insulin Resistance business Biomarkers medicine.drug |
| Zdroj: | Clinical Laboratory. 61 |
| ISSN: | 1433-6510 |
| Popis: | BACKGROUND Chemerin is an important risk factor of insulin resistance. Non-alcoholic fatty liver has typical characteristics of insulin resistance. The aim of this study was to explore the potential role of chemerin in NAFLD. METHODS 45 subjects included 22 control subjects (A group) and 23 subjects diagnosed with non-alcoholic fatty liver disease (B group) participated in the study. 23 patients in the NAFLD group received oral daily metformin at a dose of 20 mg/kg/day for 24 weeks follow-up. Chemerin and insulin resistance markers were determined at baseline and 24 weeks. RESULTS The levels of WHR, BMI, FINS, HOMA-IR, TG, ALT, AST, and Chemerin in B group were significantly higher than A group. After 24 weeks of metformin treatment, the levels of WHR, AST, ALT, TG, chemerin and HOMA-IR were significantly reduced (p < 0.05) and other indexes were not changed significantly. Correlation analysis indicated that serum chemerin concentrations were positively correlated with BMI, WHR, HOMA-IR, FINS, TG, ALT, and AST levels. Logistic regression analysis showed chemerin, TG, and ALT were independent variables associated with NAFLD. CONCLUSIONS These findings showed a significant increase of chemerin level in NAFLD patients. Metformin treatment can improve NAFLD and decrease the level of chemerin. Chemerin, TG, and ALT were independent variables associated with NAFLD. |
| Databáze: | OpenAIRE |
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