Studies on the plasma membrane of normal and psoriatic keratinocytes. 3. Uptake of labelled sugars and their incorporation into glycoconjugates
| Autor: | H. Roelfzema, P.D. Mier, P.E.J. Erp, J.M. Gommans, Mieke Bergers |
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| Rok vydání: | 1981 |
| Předmět: |
Time Factors
Glycoconjugate Dermatology In Vitro Techniques Fucose Lesion chemistry.chemical_compound medicine Humans Psoriasis Incubation Glycoproteins Skin chemistry.chemical_classification Epidermis (botany) Cell Membrane Metabolism In vitro Membrane chemistry Biochemistry Carbohydrate Metabolism Keratins Proteoglycans medicine.symptom Epidermis Glycolipids |
| Zdroj: | The British journal of dermatology. 104(6) |
| ISSN: | 0007-0963 |
| Popis: | SUMMARY We report the uptake of four labelled sugars by keratinocytes isolated from normal epidermis, psoriatic ‘uninvolved’ skin and psoriatic lesions. Our findings include the following: 1 The rate of uptake of all sugars by the psoriatic lesion is increased. 2 This abnormally high uptake diminishes dramatically during 22 h incubation in vitro. 3 There is a striking abnormality in the metabolism of fucose by psoriatic keratinocytes; our data suggest an increased rate of incorporation of fucose into glycoconjugates. |
| Databáze: | OpenAIRE |
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