Nitric Oxide Potentiates cAMP-Gated Cation Current by Intracellular Acidification in Feeding Neurons of Pleurobranchaea
| Autor: | Nathan G. Hatcher, Kurt Potgieter, Catherine R. McCrohan, Rhanor Gillette |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Physiology
Morpholines Intracellular pH Nitric Oxide Membrane Potentials Nitric oxide chemistry.chemical_compound Neuromodulation Cyclic AMP medicine Animals Drug Interactions Nitric Oxide Donors Neurons Membrane potential biology General Neuroscience Pleurobranchaea Extracellular Fluid Long-term potentiation Articles Hydrogen-Ion Concentration Fluoresceins biology.organism_classification Ganglia Invertebrate MOPS Cell biology Hydrazines medicine.anatomical_structure chemistry Ion Channel Gating Intracellular |
| Zdroj: | Journal of Neurophysiology. 104:742-745 |
| ISSN: | 1522-1598 0022-3077 |
| DOI: | 10.1152/jn.00021.2010 |
| Popis: | A pH-sensitive cAMP-gated cation current ( INa,cAMP) is widely distributed in neurons of the feeding motor networks of gastropods. In the sea slug Pleurobranchaea this current is potentiated by nitric oxide (NO), which itself is produced by many feeding neurons. The action of NO is not dependent on either cGMP or cAMP signaling pathways. However, we found that NO potentiation of INa,cAMPin the serotonergic metacerebral cells could be blocked by intracellular injection of MOPS buffer (pH 7.2). In neurons injected with the pH indicator BCECF, NO induced rapid intracellular acidification to several tenths of a pH unit. Intracellular pH has not previously been identified as a specific target of NO, but in this system NO modulation of INa,cAMPvia pHimay be an important regulator of the excitability of the feeding motor network. |
| Databáze: | OpenAIRE |
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