The High-Sensitivity Modified Glasgow Prognostic Score Is Superior to the Modified Glasgow Prognostic Score as a Prognostic Predictor in Patients with Resectable Gastric Cancer
| Autor: | Tatsuya Hashimoto, Risako Yamashita, Ippei Yamana, Shinsuke Takeno, Kenji Maki, Hironari Shiwaku, Yuichi Yamashita, Ryosuke Shibata |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Multivariate analysis medicine.medical_treatment Gastroenterology Prognostic score Young Adult Risk Factors Stomach Neoplasms Internal medicine medicine Humans In patient Young adult Serum Albumin Aged Neoplasm Staging Retrospective Studies Aged 80 and over biology business.industry C-reactive protein Cancer Retrospective cohort study General Medicine Middle Aged Prognosis medicine.disease Surgery C-Reactive Protein Oncology Multivariate Analysis biology.protein Gastrectomy business |
| Zdroj: | Oncology. 87:205-214 |
| ISSN: | 1423-0232 0030-2414 |
| Popis: | Aim: The aim of the present study was to evaluate the superiority of the high-sensitivity modified Glasgow prognostic score (HS-mGPS) before surgery in patients with gastric cancer. Patients and Methods: The participants of this retrospective study comprised 552 patients with gastric cancer who underwent gastrectomy at the Fukuoka University Hospital. The HS-mGPS was calculated before surgery based on cutoff values of 0.3 mg/dl for C-reactive protein and 3.5 g/dl for albumin, and correlations between the HS-mGPS and the clinicopathological parameters and prognosis were evaluated. In addition, the superiority of the HS-mGPS to the mGPS as a prognostic indicator was examined in detail. Results: The mGPS was 0 in 494 patients, 1 in 24 patients and 2 in 34 patients. In contrast, the HS-mGPS was 0 in 411 patients, 1 in 75 patients and 2 in 66 patients. Both the mGPS (p < 0.0001) and HS-mGPS (p < 0.0001) were good prognostic predictors in gastric cancer patients who underwent gastrectomy. Of the 494 patients with an mGPS of 0 before surgery, 51 and 32 exhibited an HS-mGPS of 1 and 2, respectively. The patients who exhibited migration in the HS-mGPS demonstrated a significantly more unfavorable prognosis than the patients with an HS-mGPS of 0 (p < 0.0001). The prognostic impact of the HS-mGPS was especially clear in stage I and IV patients (p = 0.0027, p = 0.017). The HS-mGPS was found to be a superior prognostic predictor compared to the mGPS in a multivariate analysis (p = 0.0002). Conclusions: The HS-mGPS before surgery is a superior prognostic predictor in patients with gastric cancer. |
| Databáze: | OpenAIRE |
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