Involvement of INF-γ functional single nucleotide polymorphism +874 T/A (rs2430561) in breast cancer risk

Autor: Hanan E. Al-Rashidi, Dalia T Hussein, Sherif Refaat, Enas Ahmed, Fatma M. El-Tantawy, Sahar Hamed
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0106 biological sciences
0301 basic medicine
ARMS-PCR
amplification refractory mutation system
polymerase chain reaction method

ER
estrogen receptor

BC
Breast cancer

medicine.disease_cause
01 natural sciences
Gastroenterology
TNF-α
tumor necrosis factor-α

Breast cancer
Polymorphism (computer science)
Genotype
HER2
human epidermal growth factor receptor 2

Biology (General)
INF-γ
CI
95% confidence intervals

PPI
poor prognostic index

C
controls

PAM50
Prediction Analysis of Microarray 50

Original Article
ICB
inflamed cells of breast

General Agricultural and Biological Sciences
INF-γ
Interferon-γ

TNBC
Triple Negative BC

medicine.medical_specialty
IRB
Institutional Review Board

QH301-705.5
Genotypes
CD
cluster of differentiation

Single-nucleotide polymorphism
NPI
the mandatory prognostic index

NK
natural killer cells

03 medical and health sciences
Internal medicine
TGF-β
transforming growth factor-β

medicine
Allele
Polymorphism
GPI
good prognostic index

business.industry
Cancer
PR
progesterone receptor

medicine.disease
IL
interleukin

OR
odds ratio

030104 developmental biology
SNPs
single nucleotide polymorphism

ISGs
INF-stimulated genes

MPI
moderate prognostic index

Gene polymorphism
Risk factor
Carcinogenesis
business
Th1
T helper1

010606 plant biology & botany
Zdroj: Saudi Journal of Biological Sciences
Saudi Journal of Biological Sciences, Vol 28, Iss 11, Pp 6289-6296 (2021)
ISSN: 2213-7106
1319-562X
Popis: According Global Cancer Statistics 2020 GLOBOCAN estimates female breast cancer was found as the most commonly diagnosed cancer, with an estimated 2.3 million new cases (11.7%), and the fourth leading cause (6.9%) of cancer death among women worldwide. Identification of new diagnostic marker sharply characterize the tumor feature is intensive need. The present work was performed to investigate the involvement of the INF-γ + 874 T/A gene polymorphism in different breast cancer prognostic factors. Polymorphism detection analysis was performed on 163 subjects from breast cancer patients, 79 with inflamed cells of breast patients and 144 controls. The gene polymorphism was detected using the amplification refractory mutation system- polymerase chain reaction method (ARMS-PCR). The distribution of INF-γ T + 874A gene polymorphism shows strong significant association between INF-γ + 874 T/A genotypes TT in BC patients (ORTT: 6.41 [95% CI = 2.72–15.1] P
Databáze: OpenAIRE