Mechanisms of the Effects of Short-Term Inhalations of Xe and O2 Gas Mixture in the Rehabilitation of Post-COVID Ventilation Failure
| Autor: | V. V. Udut, S. A. Naumov, E. V. Udut, S. S. Naumov, D. N. Evtushenko, O. N. Chumakova, G. N. Zyuz’kov |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Male
постковидные осложнения Respiratory Therapy pulmonary surfactant Xenon легочный сурфактант General Biochemistry Genetics and Molecular Biology Russia Post-Acute COVID-19 Syndrome ингаляции газовой смесью ксенона и кислорода molecular electrostatic potential post-COVID complications Administration Inhalation Humans молекулярный электростатический потенциал Lung Experimental Methods for Clinical Practice SARS-CoV-2 Respiration COVID-19 General Medicine Middle Aged Oxygen Drug Combinations Anesthetics Inhalation Хе dipalmitoylphosphatidylcholine Respiratory Insufficiency дипальмитоилфосфатидилхолин |
| Zdroj: | Bulletin of Experimental Biology and Medicine Bulletin of experimental biology and medicine. 2022. Vol. 172, № 3 № 3. P. 364-367 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | The article presents a theoretical rationale and a clinical case of relief of post-COVID ventilation failure by inhalation of Xe and O-2 gas mixture. Pneumonitis of coronavirus etiology transforms saturated phospholipids of surfactant into a solid-ordered phase, which disrupts surface tension, alveolar pneumatization, and alveolar-capillary gas exchange. Using molecular modeling (B3LYP/lanl2dz; GAUSSIAN09), we demonstrated that Xe atom due to the van der Waals dispersion interaction increases the distance between the phospholipid acyl chains providing a phase transition from the solid-ordered to liquid phase and restored the surface-active monolayer surfactant film. A clinical case confirmed that short-term inhalations of the Xe and O-2 gas mixture relieved manifestations of ventilation insufficiency and increased SpO(2) and pneumatization of the terminal parts of the lungs. |
| Databáze: | OpenAIRE |
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