Development of the Concept for Stem Cell-Based Developmental Neurotoxicity Evaluation
| Autor: | Jördis Klose, Ellen Fritsche, Saskia Wuttke, Laura Nimtz, Marta Barenys, Julia Tigges, Martin Schmuck, Stefan Masjosthusmann |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Neurotoxicity Syndrome Brain development Neurogenesis Cell Culture Techniques Apoptosis Biology Toxicology Chemical exposure 03 medical and health sciences 0302 clinical medicine Neural Stem Cells Toxicity Tests medicine Animals Humans Progenitor cell Cells Cultured Embryonic Stem Cells Cell Proliferation Developmental neurotoxicity Brain Human brain Review article 030104 developmental biology medicine.anatomical_structure Neurotoxicity Syndromes Stem cell Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Toxicological sciences : an official journal of the Society of Toxicology. 165(1) |
| ISSN: | 1096-0929 |
| Popis: | Human brain development consists of a series of complex spatiotemporal processes that if disturbed by chemical exposure causes irreversible impairments of the nervous system. To evaluate a chemical disturbance in an alternative assay, the concept evolved that the complex procedure of brain development can be disassembled into several neurodevelopmental endpoints which can be represented by a combination of different alternative assays. In this review article, we provide a scientific rationale for the neurodevelopmental endpoints that are currently chosen to establish assays with human stem/and progenitor cells. Assays covering these major neurodevelopmental endpoints are thought to assemble as building blocks of a DNT testing battery. |
| Databáze: | OpenAIRE |
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