Contribution of spinal cord biopsy to diagnosis of aquaporin-4 antibody positive neuromyelitis optica spectrum disorder

Autor: Ringelstein, M., Metz, I., Ruprecht, K., Koch, A., Rappold, J., Ingwersen, J., Mathys, C., Jarius, S., Brück, W., Hartung, H.-P., Paul, F., Aktas, O., Langel, Stefan, Hofstadt-van Oy, Ulrich, Reuss, Reinhard, Wilke, Christian, Münch, Christoph, Hellwig, Kerstin, Kleiter, Ingo, Niehaus, Sabine, Melms, Arthur, Linker, Ralf, Mayer, Christoph, Guthke, Kersten, Pellkofer, Hannah, Hoffmann, Frank, Zentner, Christian, Stangel, Martin, Trebst, Corinna, Wildemann, Brigitte, Geis, Christian, Ettrich, Barbara, Bergh,Florian Then, Wandinger, Klaus-Peter, Berthele, Achim, Hemmer, Bernhard, Kümpfel, Tania, Marziniak, Martin, Böttcher, Tobias, Rommer,Paulus S., Neuhaus, Oliver, Sieb, Jörn-Peter, Veauthier, Christian, Faiss, Jürgen, Kern, Peter, Ziemann, Ulf, Tumani, Hayrettin, Lauda, Florian, Brettschneider, Johannes, Liebetrau, Martin, Kleinschnitz, Christoph, Schippling, Sven
Rok vydání: 2013
Předmět:
Adult
Pathology
medicine.medical_specialty
Time Factors
Biopsy
neuromyelitis optica
Neuropathology
Transverse myelitis
03 medical and health sciences
Young Adult
0302 clinical medicine
Predictive Value of Tests
longitudinally extensive transverse myelitis
medicine
Humans
Serologic Tests
longitudinally extensive spinal cord lesion
030304 developmental biology
Autoantibodies
Retrospective Studies
Aquaporin 4
spinal biopsy
aquaporin-4 antibody
0303 health sciences
Neuromyelitis optica
medicine.diagnostic_test
business.industry
Multiple sclerosis
Neuromyelitis Optica
Magnetic resonance imaging
Middle Aged
medicine.disease
Spinal cord
Magnetic Resonance Imaging
3. Good health
Spinal cord tumor
medicine.anatomical_structure
Neurology
Spinal Cord
Female
Neurology (clinical)
business
030217 neurology & neurosurgery
Biomarkers
Zdroj: Multiple sclerosis (Houndmills, Basingstoke, England). 20(7)
ISSN: 1477-0970
Popis: Longitudinally extensive transverse myelitis is characteristic but not pathognomonic for neuromyelitis optica spectrum disorders (NMOSDs) and may mimic local tumors. In this retrospective study based on a cohort of 175 NMOSD patients we identified seven patients who initially presented with a longitudinally extensive spinal cord lesion and underwent spinal cord biopsy due to magnetic resonance imaging (MRI)-suspected malignancies. Remarkably, routine neuropathology was inconclusive and did not guide the diagnostic process to anti-aquaporin-4 (AQP4)-seropositive NMOSD. Serious postoperative complications occurred in 5/7 patients and persisted during follow-up in 2/7 patients (29%). Considering these sequelae, AQP4-antibody testing should be mandatory in patients with inconclusive longitudinally extensive spinal cord lesions prior to biopsy. peerReviewed
Databáze: OpenAIRE
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