Clinical characteristics of late-life depression predicting mortality
| Autor: | Johanna M Hegeman, Radboud M. Marijnissen, Didi Rhebergen, Rob H. S. van den Brink, Carlijn Wiersema, Karen S van den Berg, Richard C. Oude Voshaar |
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| Přispěvatelé: | Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Clinical Cognitive Neuropsychiatry Research Program (CCNP), Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Aging & Later Life |
| Rok vydání: | 2019 |
| Předmět: |
lifestyle
EXCESS MORTALITY SYMPTOMS INVENTORY Comorbidity SUBTYPES Cohort Studies 03 medical and health sciences 0302 clinical medicine Medicine Humans Depression (differential diagnoses) METAANALYSIS ALL-CAUSE MORTALITY ASSOCIATIONS Aged Aged 80 and over Depressive Disorder 030214 geriatrics business.industry Depression Mortality rate minor depression ADULTS Late life depression mortality Antidepressive Agents COMMUNITY Psychiatry and Mental health 80 years and over DISEASES Geriatrics and Gerontology Pshychiatric Mental Health business Gerontology 030217 neurology & neurosurgery Demography |
| Zdroj: | AGING & MENTAL HEALTH, 1-8. ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD STARTPAGE=1;ENDPAGE=8;ISSN=1360-7863;TITLE=AGING & MENTAL HEALTH van den Berg, K S, Wiersema, C, Hegeman, J M, van den Brink, R H S, Rhebergen, D, Marijnissen, R M & Oude Voshaar, R C 2021, ' Clinical characteristics of late-life depression predicting mortality ', Aging and Mental Health, vol. 25, no. 3, pp. 476-483 . https://doi.org/10.1080/13607863.2019.1699900 Aging and Mental Health, 25(3), 476-483. Taylor and Francis Ltd. |
| ISSN: | 1364-6915 1360-7863 |
| DOI: | 10.1080/13607863.2019.1699900 |
| Popis: | Objective: Depression has been associated with increased mortality rates, and modifying mechanisms have not yet been elucidated. We examined whether specific subtypes or characteristics of late-life depression predict mortality. Methods: A cohort study including 378 depressed older patients according to DSM-IV criteria and 132 never depressed comparisons. The predictive value of depression subtypes and characteristics on the six-year mortality rate, as well as their interaction with somatic disease burden and antidepressant drug use, were studied by Cox proportional hazard analysis adjusted for demographic and lifestyle characteristics. Results: Depressed persons had a higher mortality risk than non-depressed comparisons (HR = 2.95 [95% CI: 1.41-6.16], p = .004), which lost significance after adjustment for age, sex, education, smoking, alcohol, physical activity, number of prescribed medications and somatic comorbidity. Regarding depression subtypes and characteristics, only minor depression was associated with a higher mortality risk when adjusted for confounders (HR = 6.59 [95% CI: 1.79-24.2], p = .005). Conclusions: Increased mortality rates of depressed older persons seem best explained by unhealthy lifestyle characteristics and multiple drug prescriptions. The high mortality rate in minor depression, independent of these factors, might point to another, yet unknown, pathway towards mortality for this depression subtype. An explanation might be that minor depression in later life reflects depressive symptoms due to underlying aging-related processes, such as inflammation-based sickness behavior, frailty, and mild cognitive impairment, which have all been associated with increased mortality. |
| Databáze: | OpenAIRE |
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