Chronic hepatitis C infection and sicca syndrome: a clear association with HLA DQB1*02
| Autor: | Dermot Kelleher, Emer Lawlor, Myra O'Regan, Ruth Pilkington, Richard Hagan, Susan McKiernan, Claire M. Smyth |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Hepatitis C virus Hepacivirus medicine.disease_cause Polymerase Chain Reaction Virus HLA-DQ Antigens Sicca syndrome medicine HLA-DQ beta-Chains Humans Retrospective Studies Hepatitis Hepatology biology business.industry Gastroenterology HLA-DR Antigens Hepatitis C Hepatitis C Chronic Middle Aged Viral Load medicine.disease biology.organism_classification Virology Sjogren's Syndrome Immunology Female Viral disease business Viral load |
| Zdroj: | European Journal of Gastroenterology & Hepatology. 19:493-498 |
| ISSN: | 0954-691X |
| Popis: | BACKGROUND: Hepatitis C virus infection is a major cause of nonA, nonB hepatitis worldwide. A high prevalence of immunological abnormalities has been shown to occur in patients with chronic hepatitis C virus infection. AIM: The aim of this study was to assess the development of sicca syndrome in a cohort of patients infected with a single strain of hepatitis C virus, namely genotype 1b, and correlate this with viral persistence and human leukocyte antigen type of the patients. METHODS: Ninety-five patients infected with the single strain hepatitis C virus were used in this study, 32 of whom were polymerase chain reaction-negative and 63 polymerase chain reaction-positive. Patient details were reviewed for symptoms consistent with sicca syndrome. Human leukocyte antigen class I (A, B and C) and class II (DRB and DQB1) typing was performed on all patients. Auto-antibodies were also measured. RESULTS: DQB1*02 was highly significantly associated with viral persistence (P |
| Databáze: | OpenAIRE |
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