rs6295 [C]-Allele Protects Against Depressive Mood in Elderly Endurance Athletes
| Autor: | Matthias Michlmayr, Vanessa Scheichenberger, Sonja Nistler, Alexander Pilger, Helmuth Haslacher, Peter Dal-Bianco, Oswald Wagner, Thomas M. Scherzer, Johann Lehrner, Elisabeth Ponocny-Seliger, Thomas Perkmann, Lukas Pezawas, Robert Winker, Delgerdalai Batmyagmar |
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| Rok vydání: | 2016 |
| Předmět: |
Depressive mood
Male medicine.medical_specialty Univariate model Physical exercise Polymorphism Single Nucleotide Running Physical medicine and rehabilitation Endurance training Internal medicine medicine Humans Allele Applied Psychology rs6295 Alleles Aged Psychiatric Status Rating Scales biology Athletes Depression Nuclear Proteins biology.organism_classification DNA-Binding Proteins Endocrinology Relative risk Receptor Serotonin 5-HT1A Physical Endurance Female Psychology Transcription Factors |
| Zdroj: | Journal of sportexercise psychology. 37(6) |
| ISSN: | 1543-2904 |
| Popis: | A single nucleotide variant within the promoter of the 5-hydroxytryptamine1A (5HT1A) receptor, rs6295, is part of a binding site for the transcription factor NUDR (nuclear-DEAF-1-related). We aimed to ascertain whether the rs6295 mediates the effect of exercise on depressive mood in elderly endurance athletes. We prospectively enrolled 55 elderly athletes (marathon runners/bicyclists) and 58 controls. In a controlled, univariate model, an interaction between the [C]-allele and physical activity indicated that only among athletes, the variant resulting in an imperfect NUDR binding site was associated with a lower depression score. Hence, athletes presented with a significantly lower relative risk of achieving a suspicious depression score among carriers of at least one [C]-allele. Our results suggest that the positive effect of physical exercise on depressive mood might be mediated by the 5HT1A receptor and the extent of this protective effect seems to be enhanced by the [C]-allele of the rs6295 variant. |
| Databáze: | OpenAIRE |
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