Apoptosis induced by Ibaraki virus does not affect virus replication and cell death in hamster lung HmLu-1 cells
| Autor: | Rie Watanabe, Yuya Tsuruta, Hiroyuki Iwata, Shusaku Shibutani |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Programmed cell death
040301 veterinary sciences Ibaraki virus Hamster Arbovirus Infections Biology Virus Replication Arbovirus Cell Line 0403 veterinary science 03 medical and health sciences Virology Cricetinae medicine Animals Cytotoxicity Lung 030304 developmental biology 0303 health sciences Full Paper HmLu-1 IBAV Cell Death General Veterinary apoptosis 04 agricultural and veterinary sciences medicine.disease Cell biology medicine.anatomical_structure Viral replication Apoptosis Arboviruses |
| Zdroj: | The Journal of Veterinary Medical Science |
| ISSN: | 1347-7439 0916-7250 |
| DOI: | 10.1292/jvms.18-0366 |
| Popis: | Ibaraki virus (IBAV) is an arbovirus that is transmitted by biting midges and causes Ibaraki disease in cattle. IBAV induces apoptosis in several mammalian cell lines, and apoptosis in turn facilitates IBAV replication. In addition, virus-induced apoptosis may contribute to mammalian-specific pathogenicity considering that some arboviruses induce apoptosis in mammalian cells but not in insect cells. In this study, we found that when hamster lung cells (HmLu-1) are used as a virus host, IBAV causes severe cytopathic effects with little induction of apoptosis. Furthermore, pharmacological inhibition of apoptosis did not affect IBAV-induced cytotoxicity. These results indicate the existence of an apoptosis-independent pathway in which IBAV replicates and exerts cytotoxicity in mammalian cells. |
| Databáze: | OpenAIRE |
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