Leptin and adiponectin dynamics at patients with rectal neoplasm - gender differences

Autor: Ioana Florescu, Alexandru Florescu, Dragoş Viorel Scripcariu, Viorel Scripcariu, Dumitru Branisteanu, G Dimofte, Ioana Grigoras, Stefana Catalina Bilha
Rok vydání: 2019
Předmět:
0301 basic medicine
Leptin
Male
Colorectal cancer
Physiology
Peptide Hormones
Cancer Treatment
Biochemistry
Gastroenterology
Fats
0302 clinical medicine
Surgical oncology
Weight loss
Immune Physiology
Rectal Neoplasm
Medicine and Health Sciences
Innate Immune System
Multidisciplinary
Middle Aged
Lipids
Surgical Oncology
Oncology
Physiological Parameters
030220 oncology & carcinogenesis
Medicine
Cytokines
Female
Adiponectin
Anatomy
medicine.symptom
Research Article
Clinical Oncology
medicine.medical_specialty
Surgical stress
Science
Immunology
Adipokine
Surgical and Invasive Medical Procedures
Body weight
03 medical and health sciences
Sex Factors
Adipokines
Stress
Physiological
Internal medicine
Weight Loss
Rectal carcinoma
Biomarkers
Tumor
medicine
Humans
Aged
Rectal Neoplasms
business.industry
Body Weight
Rectum
Biology and Life Sciences
Molecular Development
medicine.disease
Hormones
Gastrointestinal Tract
030104 developmental biology
Endocrinology
Immune System
Case-Control Studies
Clinical Medicine
business
Digestive System
Chemoradiotherapy
Developmental Biology
Zdroj: PLoS ONE
PLoS ONE, Vol 14, Iss 8, p e0212471 (2019)
DOI: 10.1101/541557
Popis: Background.Numerous studies associate adipokines with colorectal malignancy, but few data deal with patients suffering exclusively of rectal carcinoma (RC). Aims. We evaluated leptin and adiponectin levels in RC patients compared to healthy population and their dynamics after surgery. Material and methods. Serum leptin and adiponectin were evaluated before surgery in 59 RC consecutive patients (38 males and 21 females), and in age and weight matched healthy controls. Measurements were repeated at 24, 72 hours and 7 days after surgery. Results. Adipokine levels were higher in women. Controls had higher leptin (32.±4.34 vs 9.51±1.73 ng/ml in women and 11±2.66 vs 2.54±0.39 ng/ml in men, p=0.00048 and 0.0032) and lower adiponectin (9±0.64 vs 11.85±1.02 µg/ml in women and 7.39±0.51 vs 8.5±0.62 µg/ml in men, p=0.017 and 0.019) than RC patients. Surgery caused an increase of leptin from 5.11±0.8 to 18.7±2.42 ng/ml, p=6.85 × 108, and a decrease of adiponectin from 9.71±0.58 to 7.87±0.47 µg/ml, p=1.4 × 1010 for all RC patients and returned thereafter to the initial range at 7 days. Adipokines were correlated with body weight (BW). The significance of correlation persisted after surgery only in males, but disappeared in females. Adipokines were not modified by tumor position, presurgical chemoradiotherapy or surgical technique. Women with RC experiencing weight loss had higher adiponectin than women without weight modifications (p
Databáze: OpenAIRE
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