Comparison of the Effects of Sevoflurane and Desflurane on Thiol-Disulfide Homeostasis in Patients Undergoing Laparoscopic Cholecystectomy
| Autor: | Muge Kurtsahin, Levent Ozturk, Merve Ergin, Salim Neselioglu, Cihan Doger, Abdulkadir But, Ayça Tuba Dumanli Özcan, Aysun Ersen Yungul |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Insufflation Laparoscopic surgery 030213 general clinical medicine lcsh:R5-920 business.industry medicine.medical_treatment Ischemia General Medicine medicine.disease Sevoflurane 03 medical and health sciences Desflurane 0302 clinical medicine chemistry 030202 anesthesiology Anesthesia Thiol medicine Original Article business lcsh:Medicine (General) Laparoscopic cholecystectomy Homeostasis medicine.drug |
| Zdroj: | Eurasian Journal of Medicine, Vol 51, Iss 1, Pp 70-74 (2019) |
| ISSN: | 1308-8742 1308-8734 |
| Popis: | OBJECTIVE: This study aims to compare the effects of different inhalation anesthetics on oxidative status by measuring thiol-disulfide homeostasis in laparoscopic cholecystectomy surgeries. The effect of inhaler agents on thiol-disulfide homeostasis that shows the oxidative status in laparoscopic cholecystectomy is unknown. MATERIALS AND METHODS: In this study, 71 patients planned to undergo laparoscopic cholecystectomy under general anesthesia were included. They were divided into two groups: desflurane (group D, n: 35) and sevoflurane (group S, n: 36). Blood samples were taken before induction (T1), at 30th minute of insufflation (T2) (30th min of ischemia), and at 30th min postdeflation (T3) (30th min of reperfusion). The native thiols (−SH) and total thiols (−SH+ −SS) were determined. The amounts of disulfide (−SS), disulfide/native thiol percent ratios (−SS/−SH), disulfide/total thiol percent ratios (−SS/−SH+−SS), and native thiol/total thiol percent ratios (−SH/−SH+ −SS) were calculated. RESULTS: In the sevoflurane group, preoperative values and intraoperative 30th-minute SS–SH ratio were significantly reduced (p=0.017). In the desflurane group, intraoperative native thiol values and postdeflation levels significantly decreased compared to those in the preoperative values (p |
| Databáze: | OpenAIRE |
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