Microbial metabolism. Part 6. Metabolites of 3- and 7-hydroxyflavones
| Autor: | Daneel Ferreira, Wimal Herath, Amber Lynn Hale, Ikhlas A. Khan, Julie Rakel Mikell |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
chemistry.chemical_classification
Flavonoids Aspergillus Aspergillus alliaceus Spectrometry Mass Electrospray Ionization Magnetic Resonance Spectroscopy biology Bacteria Spectrophotometry Infrared Chemistry Stereochemistry Flavonoid Microbial metabolism Beauveria bassiana Nocardia General Chemistry General Medicine biology.organism_classification Biochemistry Drug Discovery Fermentation |
| Zdroj: | Chemicalpharmaceutical bulletin. 54(3) |
| ISSN: | 0009-2363 |
| Popis: | Fermentation of 3-hydroxyflavone (1) with Beauveria bassiana (ATCC 13144) yielded 3,4'-dihdroxyflavone (3), flavone 3-O-beta-D-4-O-methylglucopyranoside (4) and two minor metabolites. 7-Hydroxyflavone (2) was transformed by Nocardia species (NRRL 5646) to 7-methoxyflavone (5) whilst Aspergillus alliaceus (ATCC 10060) converted it to 4',7-dihydroxyflavone (6). Flavone 7-O-beta-D-4-O-metylglucopyranoside (7) and 4'-hydroxyflavone 7-O-beta-D-4-O-methylglucopyranoside (8) were the metabolic products of 7-hydroxyflavone (2) when fermented with Beauveria bassiana (ATCC 7159). One of the minor metabolites of 3-hydroxyflavone (1) was tentatively assigned a beta'-chalcanol structure (9). Compounds 4, 7 and 8 are reported as new compounds. Structure elucidation of the metabolites was based on spectroscopic data. |
| Databáze: | OpenAIRE |
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