Biological disposition of antibilharzial antimony drugs. II. Antimony fate and uptake by Schistosoma haematobium eggs in man
| Autor: | N. I. Girgis, A.A.Abdel Rassoul, Moustafa M. Mansour, A. R. Schulert, Ellicott McConnell, Zoheir Farid |
|---|---|
| Rok vydání: | 1966 |
| Předmět: |
Antimony
Antimony potassium tartrate Immunology chemistry.chemical_element Urine In Vitro Techniques Pharmacology Excretion chemistry.chemical_compound Animal science Blood plasma medicine Animals Humans Anthelmintics Schistosoma haematobium biology General Medicine biology.organism_classification Infectious Diseases chemistry Dimercaptosuccinic acid Schistosoma Antimonial Parasitology Oils medicine.drug |
| Zdroj: | Experimental Parasitology. 18:397-402 |
| ISSN: | 0014-4894 |
| DOI: | 10.1016/0014-4894(66)90040-3 |
| Popis: | Comparative antimony disposition was investigated after the administration of three antimonial drugs to patients infected with Schistosoma haematobium; the drugs were sodium antimony dimercaptosuccinate (Astiban®), antimony dimercaptosuccinic acid (Astiban Acid in Oil®), and tartar emetic. Samples investigated were plasma, red blood cells, urine, and S. haematobium eggs excreted with the urine. After treatment with Astiban Acid in Oil, the antimony concentration in eggs excreted in the urine was found to average 2.0 times greater than in eggs from patients receiving Astiban throughout the course of treatment and for a few days thereafter. This ratio declined to an average of 1.4 for the interval from 15 days to 2 months after therapy. The antimony concentration in excreted eggs after tartar emetic is approximately ten times that after Astiban at the same dose level. Treatment with tartar emetic results in considerably less residual antimony than the other preparations. After 2.5 mg/kg tartar emetic, 49% of the antimony is excreted in the first 24 hours and 56% in the first week, whereas for Astiban at the 3.1 mg/kg level the 24-hour antimony excretion was 13.8% and the week excretion 23.4%. The antimony content of these doses is approximately 0.8 mg/kg in both cases. Antimony excretion after Astiban Acid in Oil is much lower than for Astiban. Low doses of Astiban give a relatively higher uptake of antimony in excreted eggs, a lower urinary excretion, and a higher red cell uptake in comparison to plasma. |
| Databáze: | OpenAIRE |
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