Association between gallstones and the risk of biliary tract cancer: a systematic review and meta-analysis
| Autor: | Aesun Shin, Sooyoung Cho, Nan Song, Woosung Kim, Dan Huang, Hyundeok Joo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Ampulla of Vater Gallstones Gastroenterology Risk Assessment Cholangiocarcinoma Cohort Studies 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Risk factor Gallbladder cancer business.industry General Medicine Odds ratio Publication bias medicine.disease Gallbladder neoplasms medicine.anatomical_structure Biliary Tract Neoplasms 030220 oncology & carcinogenesis Meta-analysis Case-Control Studies Bile duct neoplasms 030211 gastroenterology & hepatology Systematic Review business Cohort study |
| Zdroj: | Epidemiology and Health |
| ISSN: | 2092-7193 |
| Popis: | OBJECTIVES: Biliary tract cancers (BTCs) are rare but highly fatal. Although the etiology of BTC is poorly understood, gallstones are proposed to be a major risk factor. We conducted a systematic review and meta-analysis to examine the associations between gallstone characteristics and BTC risk.METHODS: We searched the MEDLINE, Embase, and Cochrane Central databases and systematically reviewed cohort and case-control studies published before April 9, 2018. All the included studies reported appropriate risk estimates and confidence intervals (CIs) for associations between the presence, size, number, or duration of gallstones and the risk of BTC, including gallbladder cancer (GBC), extrahepatic bile duct cancer (EBDC), and ampulla of Vater cancer (AOVC). Summary odds ratios (ORs) and their 95% CIs were calculated using a random-effects model in the meta-analysis. Subgroup analyses were conducted to inspect sources of potential heterogeneity, and the Egger test was performed to assess publication bias.RESULTS: Seven cohort studies and 23 case-control studies in Asian, European, and American populations were included. The presence of gallstones was associated with an increased risk of BTC (OR, 4.38; 95% CI, 3.23 to 5.93; I2=91.2%), GBC (OR, 7.26; 95% CI, 4.33 to 12.18), EBDC (OR, 3.17; 95% CI, 2.24 to 4.50), and AOVC (OR, 3.28; 95% CI, 1.33 to 8.11). Gallstone size (>1 vs. |
| Databáze: | OpenAIRE |
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