Factors That Predict Biological Aggressiveness in Estrogen Receptor–Positive / Human Epidermal Growth Factor Receptor 2–Negative / Lymph Node–Negative Breast Cancer
| Autor: | George M. Fuhrman, Ralph L. Corsetti, Ashley H. McMann, Amy E. Rivere, Lauren N. Slattery, Lauren E. Arthur, Aimee M. Mackey |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty recurrence Sentinel lymph node Estrogen receptor Lower risk Metastasis 03 medical and health sciences receptors–progesterone sentinel lymph node 0302 clinical medicine Breast cancer Internal medicine Progesterone receptor medicine 030212 general & internal medicine neoplasm staging Original Research medicine.diagnostic_test business.industry receptors–estrogen General Medicine medicine.disease 030220 oncology & carcinogenesis immunohistochemistry Immunohistochemistry Breast neoplasms business Oncotype DX |
| Zdroj: | The Ochsner Journal |
| ISSN: | 1524-5012 |
| Popis: | Background: Traditionally, breast cancer is staged using TNM criteria: tumor size (T), nodal status (N), and metastasis (M). The Oncotype DX assay provides a recurrence score (RS) based on genomics that predicts the likelihood of distant recurrence in estrogen receptor–positive (ER+)/human epidermal growth factor receptor 2–negative (HER2–)/lymph node–negative (LN–) tumors. Methods: We retrospectively reviewed the medical records of patients with ER+/HER2–/LN– breast cancer tumors who were evaluated between 2007 and 2017 with Oncotype DX RS. We compared the RS to tumor size, patient age, progesterone receptor (PR) status, and LN immunohistochemistry to assess for factors that may independently predict recurrence risk. We also compared tumor size to tumor grade. Results: The data set included 296 tumors: 248 ER+/PR-positive (PR+)/HER2– and 48 ER+/PR-negative (PR–)/HER2–. RS ranged from 0 to 66, patient age ranged from 33 to 77 years, and tumor size ranged from 1 to 65 mm. No significant correlation was found between age and RS (r=–0.073, P=0.208). PR– tumors had a significantly higher RS regardless of size (PR– mean RS 30.8 ± 12.7; PR+ mean RS 16.3 ± 7.3; t(53)=7.6, P |
| Databáze: | OpenAIRE |
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