Substituted 1,3,4-thiadiazoles with anticonvulsant activity. 1. Hydrazines
| Autor: | Malcolm Myers, Peter Myers, John F. Saville, Donald S. Walter, Christopher B. Chapleo, Michael R. Stillings, Ian F. Tulloch, Alan C. B. Smith, Anthony P. Welbourn |
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| Rok vydání: | 1986 |
| Předmět: |
Phenytoin
Male Chemistry Stereochemistry medicine.medical_treatment Rats Inbred Strains Carbamazepine Rats Anticonvulsant Agent Structure-Activity Relationship Anticonvulsant Hydrazines Thiadiazoles Drug Discovery medicine Molecular Medicine Moiety Animals Phenobarbital Anticonvulsants Hydrazine (antidepressant) medicine.drug |
| Zdroj: | Journal of medicinal chemistry. 29(11) |
| ISSN: | 0022-2623 |
| Popis: | The synthesis and anticonvulsant activity of a series of 2-aryl-5-hydrazino-1,3,4-thiadiazoles are described. The combination of preferred aromatic substituents in the 2-position coupled with alkyl substitution on the hydrazine moiety led to a number of potent compounds lacking sedation, ataxia, or lethality. 5-(2-Biphenylyl)-2-(1-methylhydrazino)-1,3,4-thiadiazole (4m) represents a new class of anticonvulsant agent and compares favorably with the standard drugs phenytoin, phenobarbital, and carbamazepine. |
| Databáze: | OpenAIRE |
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