Chrysanthemum morifolium extract improves hypertension-induced cardiac hypertrophy in rats by reduction of blood pressure and inhibition of myocardial hypoxia inducible factor-1alpha expression

Autor:	Mei-Lin Xie, Tian Gao, Xiang Zhou, Zeng-Yan Zhu
Rok vydání:	2016
Předmět:	Male 0301 basic medicine medicine.medical_specialty Chrysanthemum Pharmaceutical Science Blood Pressure Cardiomegaly Vasodilation Flowers Renovascular hypertension Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Internal medicine Drug Discovery medicine Animals Carnitine Receptor Pharmacology biology Plant Extracts Myocardium Chrysanthemum morifolium General Medicine Peroxisome Hypoxia-Inducible Factor 1 alpha Subunit biology.organism_classification Pyruvate dehydrogenase complex medicine.disease Rats 030104 developmental biology Blood pressure Endocrinology Complementary and alternative medicine 030220 oncology & carcinogenesis Hypertension Molecular Medicine medicine.drug
Zdroj:	Pharmaceutical Biology. 54:2895-2900
ISSN:	1744-5116 1388-0209
DOI:	10.1080/13880209.2016.1190764
Popis:	Chrysanthemum morifolium Ramat. (Asteraceae) extract (CME) possesses a vasodilator effect in vitro. However, the use of polyphenol-rich CME in the treatment of hypertension-induced cardiac hypertrophy has not been reported.We investigated the effect of polyphenol-rich CME on hypertension-induced cardiac hypertrophy in rats and its possible mechanism of action.The Sprague-Dawley rat model with cardiac hypertrophy was induced by renovascular hypertension. The blood pressure, cardiac weight index, free fatty acids (FFA) in serum and myocardium, and protein expressions of myocardial hypoxia inducible factor-1α (HIF-1α), peroxisome proliferator-activated receptor α (PPARα), carnitine palmitoyltransferase-1a (CPT-1a), pyruvate dehydrogenase kinase-4 (PDK-4) and glucose transporter-4 (GLUT-4) were measured after treating hypertensive rats with polyphenol-rich CME of anthodia 75-150 mg/kg once daily for 4 weeks. A myocardial histological examination was also conducted.After CME treatment, the blood pressure, cardiac weight and cardiac weight index decreased by 5.7-9.6%, 9.2-18.4% and 10.9-20.1%, respectively, and the cardiomyocyte cross-sectional area also decreased by 8.3-30.4%. The CME treatment simultaneously decreased the FFA in serum and myocardium and protein expressions of myocardial HIF-1α and GLUT-4, and increased the protein expressions of myocardial PPARα, CPT-1a and PDK-4, especially in the CME 150 mg/kg group (p 0.05 or p 0.01).Polyphenol-rich CME may alleviate hypertensive cardiac hypertrophy in rats. Its mechanisms may be related to the reduction of blood pressure and amelioration of the myocardial energy metabolism. The latter may be attributed to the inhibition of HIF-1α expression and subsequent modulation of PPARα-mediated CPT-1a, PDK-4 and GLUT-4 expressions.
Databáze:	OpenAIRE
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