Narcolepsy in orexin Knockout Mice
| Autor: | Masashi Yanagisawa, Masamitsu Nakazato, Charlotte E. Lee, S. Clay Williams, Thomas Fitch, Joel K. Elmquist, Richard M. Chemelli, Thomas E. Scammell, Yaz Y. Kisanuki, James A. Richardson, Jon T. Willie, Clifford B. Saper, Christopher M. Sinton, Robert E. Hammer, Yumei Xiong |
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| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Biochemistry Genetics and Molecular Biology(all) digestive oral and skin physiology Biology medicine.disease TCS-OX2-29 General Biochemistry Genetics and Molecular Biology Orexin receptor Orexin Orexin-A Endocrinology SB-334867 nervous system Internal medicine mental disorders medicine Orexin antagonist Almorexant hormones hormone substitutes and hormone antagonists psychological phenomena and processes Narcolepsy medicine.drug |
| Zdroj: | Cell. 98:437-451 |
| ISSN: | 0092-8674 |
| Popis: | Neurons containing the neuropeptide orexin (hypocretin) are located exclusively in the lateral hypothalamus and send axons to numerous regions throughout the central nervous system, including the major nuclei implicated in sleep regulation. Here, we report that, by behavioral and electroencephalographic criteria, orexin knockout mice exhibit a phenotype strikingly similar to human narcolepsy patients, as well as canarc-1 mutant dogs, the only known monogenic model of narcolepsy. Moreover, modafinil, an anti-narcoleptic drug with ill-defined mechanisms of action, activates orexin-containing neurons. We propose that orexin regulates sleep/wakefulness states, and that orexin knockout mice are a model of human narcolepsy, a disorder characterized primarily by rapid eye movement (REM) sleep dysregulation. |
| Databáze: | OpenAIRE |
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