ANTIOXIDANT AND CYTOTOXIC EFFECTS OF CURCUMA MANGGA AND BOSENBERGIA ROTUNDA ETHANOLIC EXTRACTS ON MCF-7 CANCER CELL LINES
| Autor: | Mohd Hamzah Mohd Nasir, Mohd Hazim Zakaria, Tamil Chelvan Meenakshi Sundram |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
History
c. mangga Antioxidant antioxidant biology Traditional medicine Chemistry DPPH b. rotunda ethanolic extracts medicine.medical_treatment biology.organism_classification Computer Science Applications Education Rhizome chemistry.chemical_compound bosenbergia rotunda MCF-7 Rotunda medicine Cytotoxic T cell Zingiberaceae MTT assay lcsh:Science (General) lcsh:Q1-390 |
| Zdroj: | Science Heritage Journal, Vol 3, Iss 2, Pp 10-14 (2019) |
| ISSN: | 2521-0866 2521-0858 |
| Popis: | Curcuma mangga and Bosenbergia rotunda which belongs to Zingiberaceae family are largely distributed in South East Asian countries including Malaysia. These plants have been traditionally used for treatment of various diseases. In this research we focused on determining the antioxidant and cytotoxic activity of C. mangga and B. rotunda ethanolic extracts. Initially, in this study, ethanolic extracts from rhizomes of C. mangga and B. rotunda were obtained through Soxhlet extraction method. 12.6% and 3.5% of crude extract were obtained from C. mangga and B. rotunda respectively. For MTT assay, the IC50 values are 207µg/ml and 31.96 µg/ml for C. mangga and B. rotunda respectively. Meanwhile for the antioxidant activity using DPPH assay, C. mangga showed higher antioxidant activity with IC50 values of 1073µg/ml compared to B. rotunda with IC50 values of 578µg/ml. It can be concluded both extracts showed low inhibitory effect on MCF-7 cancer cells growth and DPPH free radical activity. |
| Databáze: | OpenAIRE |
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