Oxysterols: Old Tale, New Twists
| Autor: | Ingrid C. Gelissen, Andrew J. Brown, Laura J. Sharpe, Isabelle M. Capell-Hattam, Winnie Luu |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pharmacology Oxysterol Biology Toxicology Cell function Hedgehog signaling pathway Sterols 03 medical and health sciences Cholesterol 030104 developmental biology Biochemistry polycyclic compounds Animals Homeostasis Humans Hedgehog Proteins lipids (amino acids peptides and proteins) Neuroscience Cholesterol homeostasis |
| Zdroj: | Annual Review of Pharmacology and Toxicology. 56:447-467 |
| ISSN: | 1545-4304 0362-1642 |
| Popis: | Oxysterols have long been known for their important role in cholesterol homeostasis, where they are involved in both transcriptional and posttranscriptional mechanisms for controlling cholesterol levels. However, they are increasingly associated with a wide variety of other, sometimes surprising cell functions. They are activators of the Hedgehog pathway (important in embryogenesis), and they act as ligands for a growing list of receptors, including some that are of importance to the immune system. Oxysterols have also been implicated in several diseases such as neurodegenerative diseases and atherosclerosis. Here, we explore the latest research into the roles oxy-sterols play in different areas, and we evaluate the current evidence for these roles. In addition, we outline critical concepts to consider when investigating the roles of oxysterols in various situations, which includes ensuring that the concentration and form of the oxysterol are relevant in that context—a caveat with which many studies have struggled. |
| Databáze: | OpenAIRE |
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