Benefit of re-operation and salvage therapies for recurrent glioblastoma multiforme: results from a single institution
| Autor: | Kevin Petrecca, S. Owen, Luis Souhami, Bassam Abdulkarim, Melissa Azoulay, Marie-Christine Guiot, Fabiano Santos, Ayman Oweida, Valerie Panet-Raymond, George Shenouda |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Reoperation Re-Irradiation Cancer Research medicine.medical_specialty Multivariate analysis Bevacizumab medicine.medical_treatment Kaplan-Meier Estimate Neurosurgical Procedures 03 medical and health sciences 0302 clinical medicine medicine Humans Combined Modality Therapy Aged Proportional Hazards Models Retrospective Studies Salvage Therapy Chemotherapy Temozolomide Brain Neoplasms Proportional hazards model business.industry Retrospective cohort study Middle Aged Surgery Treatment Outcome Neurology Oncology Chemotherapy Adjuvant 030220 oncology & carcinogenesis Disease Progression Female Neurology (clinical) Neoplasm Recurrence Local Glioblastoma business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Neuro-Oncology. 132:419-426 |
| ISSN: | 1573-7373 0167-594X |
| DOI: | 10.1007/s11060-017-2383-2 |
| Popis: | The optimal management of recurrent glioblastoma (GBM) has yet to be determined. We aim to assess the benefits of re-operation and salvage therapies (chemotherapy and/or re-irradiation) for recurrent GBM and to identify prognostic factors associated with better survival. All patients who underwent surgery for GBM between January 2005 and December 2012 followed by adjuvant radiotherapy, and who developed GBM recurrence on imaging were included in this retrospective study. Univariate and multivariate analysis was performed using Cox models in order to identify factors associated with overall survival (OS). One hundred and eighty patients treated to a dose of 60 Gy were diagnosed with recurrent GBM. At a median follow-up time of 6.2 months, the median survival (MS) from time of recurrence was 6.6 months. Sixty-nine patients underwent repeat surgery for recurrence based on imaging. To establish the benefits of repeat surgery and salvage therapies, 68 patients who underwent repeat surgery were matched to patients who did not based on extent of initial resection and presence of subventricular zone involvement at recurrence. MS for patients who underwent re-operation was 9.6 months, compared to 5.3 months for patients who did not have repeat surgery (p |
| Databáze: | OpenAIRE |
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