Enhanced lymphokine-activated killer cell activity by an immunomodulator, Roquinimex
| Autor: | M. R. G. Silva, F. Vaz, J. L. Ascensao |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Cancer Research
Cellular immunity Lymphocyte medicine.medical_treatment Bone Marrow Cells Cell Count chemical and pharmacologic phenomena Biology Lymphocyte Activation Natural killer cell Adjuvants Immunologic Bone Marrow Tumor Cells Cultured medicine Humans Killer Cells Lymphokine-Activated Cyclophosphamide Cells Cultured Roquinimex Lymphokine-activated killer cell Bone Marrow Purging Immunotherapy Hematopoietic Stem Cells Stimulation Chemical Bone marrow purging Killer Cells Natural Phenotype medicine.anatomical_structure Oncology Immunology Hydroxyquinolines Leukocytes Mononuclear Leukemia Erythroblastic Acute Bone marrow Cell Division Research Article medicine.drug |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Roquinimex (Roq) is an immunomodulator known to stimulate cellular immune responses. It is currently used for immunotherapy after bone marrow transplantation (BMT). One of the major features of this compound is an enhancement of natural killer (NK) cell activity and numbers. We studied the in vitro effect of Roq on human peripheral blood NK and adherent lymphokine-activated killer cell (ALAK) activities. In cultures supplemented with recombinant interleukin 2 (rIL-2) (1000 U ml-1) and Roq a significant increase in NK and LAK function was observed without a parallel increase in cell numbers. We also examined the generation of NK cells from human bone marrow (BM) immature progenitors, obtained by purging with 4-hydroperoxycyclophosphamide (4HC). NK cell numbers and activity were both increased when cultures with rIL-2 (10 U ml-1) were supplemented with Roq. These results confirm findings obtained in vivo and in vitro in the murine system and suggest that Roq is an active agent on these lymphoid populations. These properties and good tolerability make Roq an attractive tool for immunotherapy. |
| Databáze: | OpenAIRE |
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