Priming of human CD4+ antigen-specific T cells to undergo apoptosis by HIV-infected monocytes. A two-step mechanism involving the gp120 molecule
| Autor: | André Capron, A G Dalgleish, Hervé Groux, F Cottrez, F Manca, F Arenzana-Seisdedos |
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| Rok vydání: | 1997 |
| Předmět: |
CD4-Positive T-Lymphocytes
Transcription Genetic CD4 antigen T cell Antigen-Presenting Cells Priming (immunology) Apoptosis HIV Envelope Protein gp120 Biology Lymphocyte Activation Genes env Monocytes chemistry.chemical_compound Interleukin 21 Proviruses Antigen medicine Humans Cytotoxic T cell Antigen-presenting cell virus diseases General Medicine medicine.anatomical_structure chemistry Genes tat Immunology HIV-1 Research Article |
| Zdroj: | Journal of Clinical Investigation. 99:257-266 |
| ISSN: | 0021-9738 |
| DOI: | 10.1172/jci119154 |
| Popis: | The study of the pathology of HIV-1 infection in chimpanzees supports the idea of the crucial role of HIV-infected monocytes in the pathogenesis of AIDS, although viral mechanisms that lead to T cell dysfunction and deletion during HIV infection are still unclear. We show here that HIV-1-infected antigen-presenting monocytes (APCs) are able to prime in vitro non-HIV-infected antigen-specific CD4+ T cell lines or peripheral blood CD4+ T cells to undergo apoptosis after antigen-specific restimulation. The priming of T cells for apoptosis occurs in the absence of HIV replication in the T cells. Priming for apoptosis required two concomitant signals present on the same APC, an antigenic stimulus and a second signal provided by the HIV gp120 protein as demonstrated by the use as APCs of EBV-LCLs infected with different recombinant deleted proviruses or transfected with different HIV proteins. These results provide a mechanism for the priming for apoptosis of T cells in HIV-infected patients, implicating a role for HIV-infected APCs in the induction of T cell dysfunction and depletion in AIDS. |
| Databáze: | OpenAIRE |
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