Effect of endothelin on systemic and regional hemodynamics in rats
| Autor: | Guillermo Ais, JoséM. López-Novoa, JoséM. Romeo, Cesar Novo, Antonio López-Farré |
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| Rok vydání: | 1989 |
| Předmět: |
Male
medicine.medical_specialty Hemodynamics Internal medicine Animals Medicine Cardiac Output Pharmacology business.industry Endothelins Rats Inbred Strains Rats medicine.anatomical_structure Endocrinology Regional Blood Flow Anesthesia Renal blood flow Injections Intravenous Circulatory system cardiovascular system Vascular resistance Vascular Resistance Peptides business Splanchnic Endothelin receptor Blood vessel Artery |
| Zdroj: | European Journal of Pharmacology. 170:113-116 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(89)90144-1 |
| Popis: | In this study we analyzed the changes in systemic haemodynamics induced by endothelin, 1 nmol/kg, given as an i.v. bolus to anaesthetized rats. Endothelin induced a dramatic decrease in cardiac output whereas the total peripheral resistance increased more than two times. In addition, renal blood flow decreased while renal vascular resistance increased to a similar extent. A marked decrease in blood flow to the splanchnic organs was also observed. In conclusion, endothelin seems to modulate peripheral vasomotor tone, at least under certain conditions. |
| Databáze: | OpenAIRE |
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