Inhibitory Activity of Hydroxytyrosol against Streptolysin O-Induced Hemolysis
| Autor: | Mika Kobayashi, Jun Suzuki, Yoshio Kodera, Kazuyuki Sogawa, Akihiro Sanda, Masafumi Fukuyama |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
genetic structures 030106 microbiology medicine.disease_cause Hemolysis Applied Microbiology and Biotechnology Microbiology Inhibitory Concentration 50 03 medical and health sciences chemistry.chemical_compound Anti-Infective Agents Bacterial Proteins Olea medicine Animals Blood Cells biology Plant Extracts Chemistry Streptococcus Public Health Environmental and Occupational Health Respiratory infection Phenylethyl Alcohol medicine.disease biology.organism_classification eye diseases 030104 developmental biology Streptolysins Streptococcus pyogenes Hydroxytyrosol Rheumatic fever Streptolysin Rabbits Bacteria |
| Zdroj: | Biocontrol Science. 23:77-80 |
| ISSN: | 1884-0205 1342-4815 |
| Popis: | Group A streptococcus is a bacterium that resides in the throat and skin and causes respiratory infection and occasionally glomerulonephritis and rheumatic fever. Streptolysin O (SLO) produced by Streptococcus pyogenes (S. pyogenes) binds to the cell membrane, particularly to that of white and red blood cells, and is toxic to the cells and tissue. In this study, we evaluated the inhibitory activity of water-soluble polyphenols in olives (Olea europaea) against SLO-induced hemolysis. Hydroxytyrosol inhibited SLO-induced hemolytic activity, and the amount required for 50% inhibition of hemolysis was 1.30 µg. These findings suggest that the water-soluble polyphenols contained in olives have inhibitory activity against SLO-induced hemolysis. |
| Databáze: | OpenAIRE |
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