Glycosuria in glomerular diseases: histopathology and clinical correlations
| Autor: | Luís Balthazar Saldanha, I. F Freitas, Emil Sabbaga, Maria Cecilia Garibaldi Marcondes, Viktoria Woronik |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Glycosuria medicine.medical_specialty endocrine system glycosuria endocrine system diseases Physiology Tubular atrophy Immunology Biophysics Serum albumin Kidney Glomerulonephritis Membranous Biochemistry Gastroenterology chemistry.chemical_compound Internal medicine medicine Humans General Pharmacology Toxicology and Pharmaceutics Glomerular diseases lcsh:QH301-705.5 Retrospective Studies Creatinine lcsh:R5-920 biology business.industry General Neuroscience nutritional and metabolic diseases Glomerulonephritis Cell Biology General Medicine Prognosis medicine.disease Kidney Tubules Blood pressure Endocrinology chemistry lcsh:Biology (General) biology.protein histopathology Female Histopathology medicine.symptom business lcsh:Medicine (General) glomerulonephritis |
| Zdroj: | Brazilian Journal of Medical and Biological Research, Volume: 31, Issue: 5, Pages: 633-637, Published: MAY 1998 Brazilian Journal of Medical and Biological Research, Vol 31, Iss 5, p 633 (1998) Brazilian Journal of Medical and Biological Research, Vol 31, Iss 5, Pp 633-637 (1998) Brazilian Journal of Medical and Biological Research v.31 n.5 1998 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
| Popis: | There are doubts about the presence of glycosuria and the progress of glomerular disease. Some reports suggest that glycosuria could be an index of a more severe tubulointerstitial lesion. We investigated the presence of glycosuria in 60 patients with primary glomerular diseases: 17 patients (28%) had glycosuria and 43 patients (72%) were glycosuria free. The two groups were similar in age, arterial pressure and sex. Serum creatinine was higher in patients with glycosuria (2.0 +/- 1.7 vs 1.3 +/- 0.9 mg/dl, P0.05). The protein excretion rate was 7.5 +/- 3.7 vs 5.3 +/- 4.2 g/day (P0.05) in patients with and without glycosuria, respectively, while serum albumin was lower in patients with glycosuria (1.7 +/- 0.6 vs 2.7 +/- 1.0 g/dl, P0.05). Several histological forms were present in the group with glycosuria, with membraneous glomerulonephritis being the most frequent. Histological evidence of tubular atrophy and interstitial fibrosis prevailed in patients with glycosuria, suggesting a poor prognosis for these patients. We may conclude that the presence of glycosuria in patients with glomerular disease is associated with more pronounced tubular atrophy and interstitial fibrosis and therefore imply a poorer prognosis. |
| Databáze: | OpenAIRE |
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