During rapid weight loss in obese children, reductions in TSH predict improvements in insulin sensitivity independent of changes in body weight or fat
| Autor: | Michael B. Zimmermann, Joanne Wildhaber-Brooks, Isabelle Aeberli, Bruno H Knöpfli, Stefanie B. Murer, Johannes Wildhaber, Andreas Jung |
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| Přispěvatelé: | University of Zurich, Aeberli, I |
| Rok vydání: | 2010 |
| Předmět: |
Leptin
Male 1303 Biochemistry endocrine system diseases Endocrinology Diabetes and Metabolism Clinical Biochemistry 10265 Clinic for Endocrinology and Diabetology population Thyrotropin morbid-obesity 1308 Clinical Biochemistry thyroid-function in-vivo Biochemistry Body fat percentage Body Mass Index Endocrinology 10183 Swiss Institute of Allergy and Asthma Research Weight loss Reference Values Insulin adolescents reference range risk education.field_of_study Fasting 1310 Endocrinology subclinical hypothyroidism 2712 Endocrinology Diabetes and Metabolism Adipose Tissue Body Composition Regression Analysis Triiodothyronine Female Thyroid function medicine.symptom hormones hormone substitutes and hormone antagonists medicine.medical_specialty Adolescent Population 610 Medicine & health 2704 Biochemistry (medical) leptin Classification of obesity Internal medicine Weight Loss medicine Humans Obesity education Triglycerides VLAG Global Nutrition Wereldvoeding business.industry Patient Selection Biochemistry (medical) Body Weight medicine.disease Thyroxine Physical Fitness Lean body mass coronary-heart-disease business Body mass index |
| Zdroj: | Journal of Clinical Endocrinology and Metabolism, 95(12), 5412-5418 Journal of Clinical Endocrinology and Metabolism 95 (2010) 12 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | Background: Although serum TSH is often elevated in obesity and may be linked to disorders of lipid and glucose metabolism, the clinical relevance of these relationships remains unclear. Subjects: Subjects were obese children and adolescents (n = 206; mean age 14 yr) undergoing rapid weight and fat loss in a standardized, multidisciplinary, 2-month, in-patient weight loss program. Design: This was a prospective study that determined thyroid function, glucose and lipid parameters, leptin, anthropometric measures, and body composition measured by dual-energy x-ray absorption at baseline and at the end of the intervention. Results: At baseline, 52% of children had TSH concentrations in the high normal range (> 2.5 mU/liter), but TSH was not correlated with body weight, body mass index SD scores, lean body mass, or body fat percentage. At baseline, independent of adiposity, TSH significantly correlated with total cholesterol (P = 0.008), low-density lipoprotein cholesterol (P = 0.013), fasting insulin (P = 0.010), homeostatic model assessment (HOMA) (P = 0.004), and leptin (P = 0.006). During the intervention, mean body fat, TSH, HOMA, and fasting insulin decreased by 21, 11, 53, and 54%, respectively. Change (Delta) in TSH did not correlate with Delta body weight or Delta body composition, but Delta TSH significantly correlated with, Delta fasting insulin and Delta HOMA, independent of Delta body weight or Delta body composition (P |
| Databáze: | OpenAIRE |
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