T lymphocyte maturation is impaired in healthy young individuals carrying trisomy 21 (Down syndrome)
| Autor: | Gian Vincenzo Zuccotti, Michela Pacei, Alessandra Viganò, Berardo di Natale, Laura Guazzarotti, Silvia Beretta, Luca Piacentini, Daria Trabattoni, Eleonora Castelletti, Cristiana Caprio, Mario Clerici, Piergiorgio Duca, Benedetta Boldrighini |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
CD4-Positive T-Lymphocytes
Male medicine.medical_specialty Down syndrome Adolescent medicine.medical_treatment Lymphocyte T-Lymphocytes CD8-Positive T-Lymphocytes Lymphocyte Activation Young Adult Arts and Humanities (miscellaneous) Reference Values Internal medicine Developmental and Educational Psychology medicine Humans Interferon gamma Child Interleukin-7 Interleukin General Medicine T lymphocyte medicine.disease Psychiatry and Mental health Interleukin 10 Neuropsychology and Physiological Psychology Cytokine medicine.anatomical_structure Endocrinology Child Preschool Pediatrics Perinatology and Child Health Immunology Cytokines Female Neurology (clinical) Down Syndrome Psychology Immunologic Memory CD8 medicine.drug |
| Zdroj: | American journal on intellectual and developmental disabilities. 114(2) |
| ISSN: | 1944-7515 |
| Popis: | Cytokine production, immune activation, T lymphocytes maturation, and serum IL-7 concentration were examined in 24 youngsters with Down syndrome and no acquired diseases (healthy Down syndrome [12 prepubertal, 13 pubertal]) and 42 age- and gender-matched controls (20 prepubertal, 22 pubertal). Results showed that a complex immune and impairment is present in healthy individuals with Down syndrome in whom interferon gamma, interleukin (IL) IL-10 production, as well as serum IL-7 concentrations and activation markers-bearing T lymphocytes were significantly augmented. Additionally, a complex skewing of post-thymic lymphocyte maturation pathways was observed in patients: significant reduction of CD4+ and CD8+ naive (RA+CCR7+) lymphocytes, significant increase of CD4+ and CD8+ central memory (RA-CCR7+), and terminally differentiated (TD) (RA+CCR7−) lymphocytes. |
| Databáze: | OpenAIRE |
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