Influence of environmental lead on membrane ion transport in a French urban male population
| Autor: | Said Hajem, Thierry Moreau, Patrick Hannaert, Joseph Lellouch, Guy Huel, Georgette Hellier, Genevieve Orssaud, Jean R. Claude, Bernard Juguet, Bernard Festy, Ricardo P. Garay |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Paris Potassium Channels Alcohol Drinking Urban Population ATPase Biological Transport Active Diaphragm pump Blood Pressure Biochemistry Ion Channels Sodium Channels Internal medicine medicine Humans Ion transporter General Environmental Science biology Chemistry Erythrocyte Membrane Smoking Age Factors Environmental exposure Environmental Exposure Membrane transport Middle Aged Potassium channel Endocrinology Lead biology.protein Cotransporter Cation transport Hair |
| Zdroj: | Environmental research. 53(2) |
| ISSN: | 0013-9351 |
| Popis: | Red cell cation transports (Na(+)-K+ pump, Na(+)-K+ cotransport system, Na(+)-Li+ countertransport, and Na+ and K+ passive permeabilities) and blood and hair lead levels were measured in 129 healthy adult Caucasians not occupationally exposed to lead. In agreement with previously reported in vitro results showing a lead-induced Na(+)-K+ ATPase inhibition, Na(+)-K+ pump activity was inversely correlated with hair lead (r = -0.18, P less than 0.05); it was not significantly correlated with blood lead. Na(+)-K+ cotransport activity was inversely correlated with blood lead contents (r = -0.23, P less than 0.05) but not with hair lead. No significant correlation was found between the remaining cation transport pathways and lead levels. It is hypothesized that environmental, long-term exposure to lead may result in pump inhibition, while a recent exposition to lead may result in inhibition of the Na(+)-K+ cotransport system. Further research is required in order to determine if red cell Na(+)-K+ pump and Na(+)-K+ cotransport activities are sensitive indicators of chronic and recent exposures to lead, respectively. |
| Databáze: | OpenAIRE |
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