Propagating Activity Patterns in Large-Scale Inhibitory Neuronal Networks
| Autor: | Xiao Jing Wang, D. Terman, John Rinzel, B. Ermentrout |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Recruitment
Neurophysiological Membrane potential Multidisciplinary Wave propagation Models Neurological Conductance Neural Inhibition Biology Inhibitory postsynaptic potential Synaptic Transmission Feedback Membrane Potentials Electrophysiology Thalamus Interneurons Postsynaptic potential Synapses GABAergic Nerve Net Reversal potential Neuroscience gamma-Aminobutyric Acid |
| Zdroj: | Science. 279:1351-1355 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.279.5355.1351 |
| Popis: | The propagation of activity is studied in a spatially structured network model of γ-aminobutyric acid–containing (GABAergic) neurons exhibiting postinhibitory rebound. In contrast to excitatory-coupled networks, recruitment spreads very slowly because cells fire only after the postsynaptic conductance decays, and with two possible propagation modes. If the connection strength decreases monotonically with distance (on-center), then propagation occurs in a discontinuous manner. If the self- and nearby connections are absent (off-center), propagation can proceed smoothly. Modest changes in the synaptic reversal potential can result in depolarization-mediated waves that are 25 times faster. Functional and developmental roles for these behaviors and implications for thalamic circuitry are suggested. |
| Databáze: | OpenAIRE |
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