Rationale and design of the myocardial microinjury and cardiac remodeling extension study in the sodium lowering in dialysate trial (Mac-SoLID study)
| Autor: | Ruvin Gabriel, Kannaiyan Samuel Rabindranath, Imad Adbi Haloob, David O. McGregor, Lukas Mathias Gerber, Alain C. Vandal, John Irvine, Joanna L. Dunlop, Janak de Zoysa, John Benedict William Schollum, Philip James Matheson, Mark R. Marshall, David Semple, Christopher John Hood |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Home hemodialysis medicine.medical_treatment Intra-dialytic hypotension Left ventricular mass law.invention Study Protocol Randomized controlled trial Renal Dialysis Cardiac magnetic resonance imaging law Dialysis Solutions Internal medicine medicine Humans Single-Blind Method Prospective Studies Dialysate Ventricular remodeling Dialysis Myocardial stunning Ventricular Remodeling Troponin T medicine.diagnostic_test business.industry Microcirculation Sodium medicine.disease Coronary Vessels Self Care Nephrology Left ventricular remodelling Blood pressure Cardiology Female Self-care hemodialysis Hemodialysis business New Zealand |
| Zdroj: | BMC Nephrology |
| ISSN: | 1471-2369 |
| DOI: | 10.1186/1471-2369-15-120 |
| Popis: | Background The Sodium Lowering in Dialysate (SoLID) trial is an ongoing a multi-center, prospective, randomised, single-blind (assessor), controlled, parallel assignment clinical trial, enrolling 96 home and self-care hemodialysis (HD) patients from 7 centers in New Zealand. The trial will evaluate the hypothesis that lower dialysate [Na+] during HD results in lower left ventricular (LV) mass. Since it’s inception, observational evidence has suggested increased mortality risk with lower dialysate [Na+], possibly due to exacerbation of intra-dialytic hypotension and subsequent myocardial micro-injury. The Myocardial Micro-injury and Cardiac Remodeling Extension Study in the Sodium Lowering In Dialysate Trial (Mac-SoLID study) aims to determine whether lower dialysate [Na+] results in (i) increased levels of high-sensitivity Troponin T (hsTnT), a well-established marker of intra-dialytic myocardial micro-injury in HD populations, and (ii) increased fixed LV segmental wall motion abnormalities, a marker of recurrent myocardial stunning and micro-injury, and (iii) detrimental changes in LV geometry due to maladaptive homeostatic mechanisms. Methods/design The SoLID trial and the Mac-SoLID study are funded by the Health Research Council of New Zealand. Key exclusion criteria: patients who dialyse > 3.5 times per week, pre-dialysis serum sodium |
| Databáze: | OpenAIRE |
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