Anthropometric biomarkers for abnormal prenatal reproductive hormone exposure in women with Mayer-Rokitanksy-Küster-Hauser syndrome, polycystic ovary syndrome, and endometriosis
Autor: | Peter M. van de Ven, Constantia J.M.A. Trimbos, Roel Schats, Marieke O. Verhoeven, Cornelis B. Lambalk, Velja Mijatovic, Henrike E. Peters, Claire H.C. Laeven |
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Přispěvatelé: | Obstetrics and gynaecology, Epidemiology and Data Science, ACS - Heart failure & arrhythmias, APH - Methodology, Amsterdam Reproduction & Development (AR&D), ACS - Atherosclerosis & ischemic syndromes |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Adult Digit ratio medicine.medical_specialty 46 XX Disorders of Sex Development medicine.drug_class Endometriosis Anal Canal Clitoris Article Congenital Abnormalities Fingers 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests medicine Humans Sex organ Mullerian Ducts Gynecology 030219 obstetrics & reproductive medicine Anthropometry business.industry Anogenital distance Obstetrics and Gynecology Reproducibility of Results Middle Aged medicine.disease Androgen Polycystic ovary Confidence interval 030104 developmental biology Reproductive Medicine Case-Control Studies Female business Body mass index Gonadal Hormones Polycystic Ovary Syndrome |
Zdroj: | Fertil Steril Peters, H E, Laeven, C H C, Trimbos, C J M A, van de Ven, P M, Verhoeven, M O, Schats, R, Mijatovic, V & Lambalk, C B 2020, ' Anthropometric biomarkers for abnormal prenatal reproductive hormone exposure in women with Mayer-Rokitanksy-Küster-Hauser syndrome, polycystic ovary syndrome, and endometriosis ', Fertility and Sterility, vol. 114, no. 6, pp. 1297-1305 . https://doi.org/10.1016/j.fertnstert.2020.06.029 Fertility and Sterility, 114(6), 1297-1305. Elsevier Inc. |
ISSN: | 1556-5653 0015-0282 |
Popis: | Objective To study whether markers of prenatal exposure to reproductive hormones are related to Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome, polycystic ovary syndrome (PCOS), and endometriosis. Design Case-control study. Comparison of sex hormone-related external genital and digital characteristics in cases and controls. Setting University hospital. Patient(s) We enrolled 172 women in four groups—women with MKRH, women with PCOS, women with endometriosis, and controls (43 in each group). Intervention(s) Measurement of two anthropometric biomarkers: anogenital distance and digit ratio. Main Outcome Measure(s) Anogenital distance was measured from the anus to the anterior clitoral surface (AGDac) and from the anus to the posterior fourchette (AGDaf). For the digit ratio we used a direct, as well as a computer-assisted graphic measurement to measure the length of the second and fourth digit. Result(s) After adjustment for body mass index and age, AGDac was the shortest in endometriosis and the longest in PCOS groups, with a mean difference of 10 mm (95% confidence interval 3.1–16.8). AGDaf but not AGDac measures were found to be significantly larger in the MRKH group, with a mean difference compared with controls of 2.6 mm (95% confidence interval 0.1–5.2). The digit ratio was not significantly different between the groups. Conclusion(s) In this study we did find limited evidence for androgen exposure during the development of MRKH. This is compatible with the hypothesis that the uterovaginal agenesis may have been the result of temporary prenatal exposure to altered gonadal hormone concentrations. For endometriosis and PCOS we confirm previously observed associations for anogenital distance reflecting possible estrogen-based and androgen-based intrauterine origins, respectively. Dutch Trial Registration Number NTR7492. |
Databáze: | OpenAIRE |
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