Healthy Cotwins Share Gut Microbiome Signatures With Their Inflammatory Bowel Disease Twins and Unrelated Patients
| Autor: | Eelco C. Brand, Marjolein A.Y. Klaassen, Ranko Gacesa, Arnau Vich Vila, Hiren Ghosh, Marcel R. de Zoete, Dorret I. Boomsma, Frank Hoentjen, Carmen S. Horjus Talabur Horje, Paul C. van de Meeberg, Gonneke Willemsen, Jingyuan Fu, Cisca Wijmenga, Femke van Wijk, Alexandra Zhernakova, Bas Oldenburg, Rinse K. Weersma, Pieter Honkoop, Rutger J. Jacobs, Cyriel Y. Ponsioen, Nanne K.H. de Boer, Yasser A. Alderlieste, Margot A. van Herwaarden, Sebastiaan A.C. van Tuyl, Maurice W. Lutgens, C. Janneke van der Woude, Wout G.M. Mares, Daan B. de Koning, Joukje H. Bosman, Juda Vecht, Anneke M.P. de Schryver, Andrea E. van der Meulen-de Jong, Marieke J. Pierik, Paul J. Boekema, Robert J. Verburg, Bindia Jharap, Jeroen M. Jansen, Pieter C.F. Stokkers, Rutger Quispel, Nofel Mahmmod, Rachel L. West, Marleen Willems, Itta M. Minderhoud, Herma H. Fidder, Fiona D.M. van Schaik, Meike M.C. Hirdes, Nynke A. Boontje, Bart L.M. Müskens, Marielle J.L. Romberg-Camps |
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| Přispěvatelé: | Center for Liver, Digestive and Metabolic Diseases (CLDM), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Translational Immunology Groningen (TRIGR), Gastroenterology and Hepatology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Biological Psychology, APH - Mental Health, APH - Methodology, APH - Health Behaviors & Chronic Diseases |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine NETHERLANDS Siderophores Crohn's Disease Inflammatory bowel disease METAGENOMICS Feces 0302 clinical medicine Risk Factors Twins Dizygotic INDEX Crohn's disease MUCOSA Microbiota Confounding Gastroenterology Middle Aged Ulcerative colitis Preclinical Phenotype Female Inflammatory Breast Neoplasms 030211 gastroenterology & hepatology Inflammatory diseases Radboud Institute for Molecular Life Sciences [Radboudumc 5] Adult Prediagnostic GENETICS Family Studies digestive system Discordant Twin Design Young Adult 03 medical and health sciences All institutes and research themes of the Radboud University Medical Center medicine Humans Ulcerative Colitis Microbiome Antigens Bacterial Hepatology business.industry Twins Monozygotic REMISSION medicine.disease Twin study digestive system diseases Gastrointestinal Microbiome POLYAMINES Cross-Sectional Studies 030104 developmental biology Metagenomics Case-Control Studies Immunology business Prediction Body mass index |
| Zdroj: | Gastroenterology, 160(6), 1970-1985. W B SAUNDERS CO-ELSEVIER INC Gastroenterology, 160(6), 1970-1985. W.B. Saunders Ltd Brand, E C, Boomsma, D I, Willemsen, G, Weersma, R K, Romberg-Camps, M J L & Dutch TWIN-IBD consortium and the Dutch Initiative on Crohn and Colitis 2021, ' Healthy cotwins share gut microbiome signatures with their inflammatory bowel disease twins and unrelated patients ', Gastroenterology, vol. 160, no. 6, pp. 1970-1985 . https://doi.org/10.1053/j.gastro.2021.01.030 Gastroenterology, 160, 1970-1985 Gastroenterology, 160, 6, pp. 1970-1985 |
| ISSN: | 0016-5085 1970-1985 |
| DOI: | 10.1053/j.gastro.2021.01.030 |
| Popis: | Background & aims: It is currently unclear whether reported changes in the gut microbiome are cause or consequence of inflammatory bowel disease (IBD). Therefore, we studied the gut microbiome of IBD-discordant and -concordant twin pairs, which offers the unique opportunity to assess individuals at increased risk of developing IBD, namely healthy cotwins from IBD-discordant twin pairs. Methods: Fecal samples were obtained from 99 twins (belonging to 51 twin pairs), 495 healthy age-, sex-, and body mass index–matched controls, and 99 unrelated patients with IBD. Whole-genome metagenomic shotgun sequencing was performed. Taxonomic and functional (pathways) composition was compared among healthy cotwins, IBD-twins, unrelated patients with IBD, and healthy controls with multivariable (ie, adjusted for potential confounding) generalized linear models. Results: No significant differences were observed in the relative abundance of species and pathways between healthy cotwins and their IBD-twins (false discovery rate |
| Databáze: | OpenAIRE |
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