Hypolipidemic Effect of Moringa oleifera Lam Leaf Powder and its Extract in Diet-Induced Hypercholesterolemic Rats
Autor: | Shahenda M. Elaby, Shahinaz A. Helmy, Nashwa F.S. Morsy, Mohammed A.A. Ghaly |
---|---|
Rok vydání: | 2017 |
Předmět: |
Male
0106 biological sciences 0301 basic medicine Medicine (miscellaneous) Blood lipids Biology Diet High-Fat 01 natural sciences Moringa 03 medical and health sciences chemistry.chemical_compound Malondialdehyde Hyperlipidemia medicine Animals Humans Aspartate Aminotransferases Triglycerides Hypolipidemic Agents Moringa oleifera Nutrition and Dietetics Traditional medicine medicine.diagnostic_test Plant Extracts Cholesterol Anticholesteremic Agents food and beverages Alanine Transaminase medicine.disease Rats Plant Leaves 030104 developmental biology Liver Biochemistry chemistry Alanine transaminase biology.protein lipids (amino acids peptides and proteins) Liver function Lipid profile 010606 plant biology & botany |
Zdroj: | Journal of Medicinal Food. 20:755-762 |
ISSN: | 1557-7600 1096-620X |
DOI: | 10.1089/jmf.2016.0155 |
Popis: | The leaves of Moringa oleifera Lam possess some potential medicinal value. The aim of this study was to evaluate the protective effect of M. oleifera leaf powder and its extract against hyperlipidemia in rats. Adult male albino rats were divided into six groups. The first group was fed on a basal diet that served as a negative control, whereas the others were fed on a high-fat diet (HFD) containing moringa leaf powder at 0.737% or 1.475% or administered daily with 200 or 400 mg dry moringa leaf extract/kg bw for 60 days. A positive control group was fed on the HFD. Serum indices related to lipid profile, oxidative status, and liver function were analyzed. Feeding rats on an HFD containing moringa leaf powder at 0.737% or an oral dose of its dry extract at 400 mg/kg bw alleviated the harmful elevation of cholesterol, triglycerides, low-density lipoprotein cholesterol, malondialdehyde, and the activities of alanine aminotransferase and aspartate aminotransferase in serum that were induced by the HFD. This is the first study demonstrating the hypocholesterolemic effect of M. oleifera leaf powder. |
Databáze: | OpenAIRE |
Externí odkaz: |