Digitized Spiral Drawing: A Possible Biomarker for Early Parkinson’s Disease
| Autor: | Susan B. Bressman, Cuiling Wang, Rachel Saunders-Pullman, Jeannie Soto-Valencia, Qiping Yu, Richard B. Lipton, Sarah Boschung, Roberto A. Ortega, Marta San Luciano, Seth L. Pullman |
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| Přispěvatelé: | Le, Weidong |
| Rok vydání: | 2016 |
| Předmět: |
Myoclonus
Male Handwriting Aging Kinematics Parkinson's disease Writing lcsh:Medicine Hands 02 engineering and technology Neurodegenerative Audiology Pathology and Laboratory Medicine Biochemistry 0302 clinical medicine Discriminative model Medicine and Health Sciences 80 and over 0202 electrical engineering electronic engineering information engineering lcsh:Science Musculoskeletal System Spiral Aged 80 and over screening and diagnosis Movement Disorders Parkinson's Disease Multidisciplinary Receiver operating characteristic analysis Physics Classical Mechanics Discriminant Analysis Neurodegenerative Diseases Parkinson Disease Middle Aged Arms Detection Neurology Area Under Curve Physical Sciences Neurological Biomarker (medicine) Female 020201 artificial intelligence & image processing Anatomy Research Article Biotechnology 4.2 Evaluation of markers and technologies Graphics tablet medicine.medical_specialty General Science & Technology and over Fingers 03 medical and health sciences Signs and Symptoms Diagnostic Medicine Clinical Research medicine Humans In patient Aged business.industry FOS: Clinical medicine Limbs (Anatomy) lcsh:R Mental illness--Diagnosis Neurosciences Biology and Life Sciences Linear discriminant analysis medicine.disease Brain Disorders ROC Curve Case-Control Studies Physical therapy Medical Devices and Equipment lcsh:Q sense organs business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | PloS one, vol 11, iss 10 PLoS ONE, Vol 11, Iss 10, p e0162799 (2016) PLoS ONE |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0162799 |
| Popis: | Author(s): San Luciano, Marta; Wang, Cuiling; Ortega, Roberto A; Yu, Qiping; Boschung, Sarah; Soto-Valencia, Jeannie; Bressman, Susan B; Lipton, Richard B; Pullman, Seth; Saunders-Pullman, Rachel | Abstract: IntroductionPre-clinical markers of Parkinson's Disease (PD) are needed, and to be relevant in pre-clinical disease, they should be quantifiably abnormal in early disease as well. Handwriting is impaired early in PD and can be evaluated using computerized analysis of drawn spirals, capturing kinematic, dynamic, and spatial abnormalities and calculating indices that quantify motor performance and disability. Digitized spiral drawing correlates with motor scores and may be more sensitive in detecting early changes than subjective ratings. However, whether changes in spiral drawing are abnormal compared with controls and whether changes are detected in early PD are unknown.Methods138 PD subjects (50 with early PD) and 150 controls drew spirals on a digitizing tablet, generating x, y, z (pressure) data-coordinates and time. Derived indices corresponded to overall spiral execution (severity), shape and kinematic irregularity (second order smoothness, first order zero-crossing), tightness, mean speed and variability of spiral width. Linear mixed effect adjusted models comparing these indices and cross-validation were performed. Receiver operating characteristic analysis was applied to examine discriminative validity of combined indices.ResultsAll indices were significantly different between PD cases and controls, except for zero-crossing. A model using all indices had high discriminative validity (sensitivity = 0.86, specificity = 0.81). Discriminative validity was maintained in patients with early PD.ConclusionSpiral analysis accurately discriminates subjects with PD and early PD from controls supporting a role as a promising quantitative biomarker. Further assessment is needed to determine whether spiral changes are PD specific compared with other disorders and if present in pre-clinical PD. |
| Databáze: | OpenAIRE |
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